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Review
. 2013 Apr 2;185(6):485-92.
doi: 10.1503/cmaj.121206. Epub 2012 Dec 10.

Emerging therapies for acute traumatic spinal cord injury

Jefferson R Wilson  1 , Nicole Forgione, Michael G Fehlings
Affiliations
Review

Emerging therapies for acute traumatic spinal cord injury

Jefferson R Wilson et al. CMAJ. .

Erratum in

  • CMAJ. 2014 Mar 4;186(4):294
No abstract available

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Figures

Figure 1:
Figure 1:
(A) Primary and secondary mechanisms of injury determining the final extent of spinal cord damage. The primary injury event starts a pathobiological cascade of secondary injury mechanisms that unfold in different phases within seconds of the primary trauma and continuing for several weeks thereafter. (B) Longitudinal section of the spinal cord after injury. The epicentre of the injury progressively expands after the primary trauma as a consequence of secondary injury events. This expansion causes an increased region of tissue cavitation and, ultimately, worsened long-term outcomes. Within and adjacent to the injury epicentre are severed and demyelinated axons. The neuroprotective agents listed act to subvert specific secondary injuries and prevent neural damage, while the neuroregenerative agents act to promote axonal regrowth once damage has occurred. ATP = adenosine triphosphate.
See this image and copyright information in PMC

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