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. 2013 Apr;27(3):203-8.
doi: 10.1007/s12149-012-0672-6. Epub 2012 Dec 11.

A hand-held beta imaging probe for FDG

Bipin Singh  1 , Brendan C Stack Jr, Samta Thacker, Valeriy Gaysinskiy, Twyla Bartel, Val Lowe, Steven Cool, Gerald Entine, Vivek Nagarkar
Affiliations

A hand-held beta imaging probe for FDG

Bipin Singh et al. Ann Nucl Med. 2013 Apr.

Abstract

Objectives: Advances in radiopharmaceuticals and clinical understanding have escalated the use of intraoperative gamma probes in surgery. However, most probes on the market are non-imaging gamma probes that suffer from the lack of ancillary information of the surveyed tissue area. We have developed a novel, hand-held digital Imaging Beta Probe™ (IBP™) to be used in surgery in conjunction with beta-emitting radiopharmaceuticals such as (18)FDG, (131)I and (32)P for real-time imaging of a surveyed area with higher spatial resolution and sensitivity and greater convenience than existing instruments.

Methods: We describe the design and validation of a hand-held beta probe intended to be used as a visual mapping device to locate and confirm excision of (18)FDG-avid primary tumors and metastases in an animal model.

Results: We have demonstrated a device which can generate beta images from (18)FDG avid lesions in an animal model.

Conclusions: It is feasible to image beta irradiation in animal models of cancer given (18)FDG. This technology may be applied to clinical mapping of tumors and/or their metastases in the operating room. Visual image depiction of malignancy may aid the surgeon in localization and excision of lesions of interest.

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Figures

Figure 1
Figure 1
(a) The prototype hand held Imaging Beta Probe™ (IBP™). (b) Close-up view of the probe head, covered by a latex sheath.
Figure 1
Figure 1
(a) The prototype hand held Imaging Beta Probe™ (IBP™). (b) Close-up view of the probe head, covered by a latex sheath.
Figure 2
Figure 2
Scanning electron micrographs of a microcolumnar CsI:Tl film, showing the typical highly uniform, well-separated microcolumns. (a) Side view, 10 μm (average) diameter columns. (b) Close-up view of the top of the film.
Figure 2
Figure 2
Scanning electron micrographs of a microcolumnar CsI:Tl film, showing the typical highly uniform, well-separated microcolumns. (a) Side view, 10 μm (average) diameter columns. (b) Close-up view of the top of the film.
Figure 3
Figure 3
(a) Modulation transfer function and (b) detective quantum efficiency for the 140 μm thick CsI:Tl microcolumnar film, measured at 28 kVp.
Figure 4
Figure 4
(a) The mini hot rod phantom placed on top of the CsI:Tl screen. (b) Beta images of the 1.1 mm holes, separated by 2.2 mm center-to-center.
Figure 4
Figure 4
(a) The mini hot rod phantom placed on top of the CsI:Tl screen. (b) Beta images of the 1.1 mm holes, separated by 2.2 mm center-to-center.
Figure 5
Figure 5
Modulation transfer function for the 140 μm thick CsI:Tl microcolumnar film, measured using 90Sr.
Figure 6
Figure 6
Example of imaging using our IBP of an animal model of oral cavity cancer, (a) tongue and (b) lymph node, both imaged ex vivo.
See this image and copyright information in PMC

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References

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Internet and Other References

    1. IntraMedical Imaging LLC; Los Angeles, CA: www.gammaprobe.com/products/betaprobe.
    1. IntraMedical Imaging LLC; Los Angeles, CA: www.intra-medical.com/beta.html.

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