Lack of association between CYP1A1 T6235C polymorphism and coronary artery disease: evidence from a meta-analysis

Abstract

A number of studies have evaluated the correlation between the cytochrome P450 1A1 (CYP1A1) T6235C polymorphism and coronary artery disease (CAD) risk, however, at present the results remain inconclusive. To provide a more robust investigation of this correlation, a meta-analysis was performed. In the present study, a systematic search of PubMed, Embase and CBM databases for studies published prior to June 6, 2012 was performed. The correlation between the CYP1A1 T6235C polymorphism and CAD risk was assessed by calculating pooled odds ratios (ORs) and 95% confidence intervals (95% CIs). Seven studies with a total of 2,903 cases and 2,304 controls were included in the meta-analysis. Overall, the CYP1A1 T6235C polymorphism was not correlated with CAD risk (C vs. T: OR=1.03; 95% CI, 0.87-1.22; P=0.728; CC vs. TT: OR=1.04; 95% CI, 0.84‑1.19; P=0.699; CC+TC vs. TT: OR=1.04; 95% CI, 0.93-1.18; P=0.478; CC vs. TC+TT: OR=1.04; 95% CI, 0.85‑1.28; P=0.704). A meta-analysis of five high-quality studies demonstrated that the CYP1A1 T6235C polymorphism is not correlated with risk of CAD in 4 genetic models. Ethnic subgroup analyses identified no significant correlation in Caucasian, Asian and African populations. The present meta-analysis study indicates that the CYP1A1 T6235C polymorphism is not correlated with CAD risk. Additional studies with a larger sample size and consistent design must be performed to confirm the present hypothesis.