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Comment
. 2013 Jan;5(1):7-9.
doi: 10.1002/emmm.201202207. Epub 2012 Dec 11.

The cancer stem cell model: B cell acute lymphoblastic leukaemia breaks the mould

James Scott McClellan  1 , Ravindra Majeti
Affiliations
Comment

The cancer stem cell model: B cell acute lymphoblastic leukaemia breaks the mould

James Scott McClellan et al. EMBO Mol Med. 2013 Jan.
No abstract available

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Figures

Figure 1
Figure 1. Contrasting cancer stem cell models

  1. AML follows a hierarchical model in which more mature blasts lose stem cell capacity.

  2. B-ALL may follow a stochastic model by which most, if not all, cells within the tumor are able to transplant the disease in xenograft models, and there is no strict hierarchy.

See this image and copyright information in PMC

Comment on

References

    1. Bernt KM, Armstrong SA. Leukemia stem cells and human acute lymphoblastic leukemia. Semin Hematol. 2009;46:33–38. - PMC - PubMed
    1. Eppert K, Takenaka K, Lechman ER, Waldron L, Nilsson B, van Galen P, Metzeler KH, Poeppl A, Ling V, Beyene J, et al. Stem cell gene expression programs influence clinical outcome in human leukemia. Nat Med. 2011;17:1086–1093. - PubMed
    1. Gentles AJ, Plevritis SK, Majeti R, Alizadeh AA. Association of a leukemic stem cell gene expression signature with clinical outcomes in acute myeloid leukemia. JAMA: J Am Med Assoc. 2010;304:2706–2715. - PMC - PubMed
    1. le Viseur C, Hotfilder M, Bomken S, Wilson K, Rottgers S, Schrauder A, Rosemann A, Irving J, Stam RW, Shultz LD, et al. In childhood acute lymphoblastic leukemia, blasts at different stages of immunophenotypic maturation have stem cell properties. Cancer Cell. 2008;14:47–58. - PMC - PubMed
    1. Majeti R. Monoclonal antibody therapy directed against human acute myeloid leukemia stem cells. Oncogene. 2011;30:1009–1019. - PubMed

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