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Comment
. 2012 Dec;2(12):1081-3.
doi: 10.1158/2159-8290.CD-12-0486.

Lineage-specific biomarkers predict response to FGFR inhibition

David C Loch  1 , Pamela M Pollock
Affiliations
Comment

Lineage-specific biomarkers predict response to FGFR inhibition

David C Loch et al. Cancer Discov. 2012 Dec.

Abstract

In this issue of Cancer Discovery, Guagnano and colleagues use a large and diverse annotated collection of cancer cell lines, the Cancer Cell Line Encyclopedia, to correlate whole-genome expression and genomic alteration datasets with cell line sensitivity data to the novel pan-fibroblast growth factor receptor (FGFR) inhibitor NVP-BGJ398. Their findings underscore not only the preclinical use of such cell line panels in identifying predictive biomarkers, but also the emergence of the FGFRs as valid therapeutic targets, across an increasingly broad range of malignancies.

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Conflict of interest statement

Disclosure of Potential Conflicts of Interest: PMP has filed a patent regarding the detection of FGFR2 mutations in endometrial cancer samples (20100111944, Method of Diagnosing, Classifying and Treating Endometrial Cancer and Precancer, filed 24 March 2008) that is relevant to this topic.

Comment on

  • FGFR genetic alterations predict for sensitivity to NVP-BGJ398, a selective pan-FGFR inhibitor.
    Guagnano V, Kauffmann A, Wöhrle S, Stamm C, Ito M, Barys L, Pornon A, Yao Y, Li F, Zhang Y, Chen Z, Wilson CJ, Bordas V, Le Douget M, Gaither LA, Borawski J, Monahan JE, Venkatesan K, Brümmendorf T, Thomas DM, Garcia-Echeverria C, Hofmann F, Sellers WR, Graus-Porta D. Guagnano V, et al. Cancer Discov. 2012 Dec;2(12):1118-33. doi: 10.1158/2159-8290.CD-12-0210. Epub 2012 Sep 20. Cancer Discov. 2012. PMID: 23002168

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