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Comment
. 2012 Dec;2(12):1084-6.
doi: 10.1158/2159-8290.CD-12-0434.

Hello out there...is anybody listening?

Rosa Anna DeFilippis  1 , Thea D Tlsty
Affiliations
Comment

Hello out there...is anybody listening?

Rosa Anna DeFilippis et al. Cancer Discov. 2012 Dec.

Abstract

Using a murine xenograft model system, Kuznetsov and colleagues show the existence of systemic interactions between a primary tumor and the growth of distal tumors in both homotypic and heterotypic tissues. Importantly, they show that the characteristics of the primary tumor govern the histologic features of the distal tumor through distinct pathways, thus providing novel opportunities for risk assessment, prognosis, prevention, and intervention.

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Figures

Figure 1
Figure 1. Results from xenograft model system
Both luminal (red arrow) and triple negative (blue arrow) breast tumors can instigate the growth of an otherwise indolent responding breast tumor. The luminal and triple negative instigating breast tumors utilize very different mechanisms of instigation, resulting in histologically distinct responding tumors. In addition, instigating breast tumors can facilitate the growth of otherwise indolent tumors from distal tissues (black arrow).
See this image and copyright information in PMC

Comment on

References

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