Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2012 Nov-Dec;26(6):469-74.
doi: 10.2500/ajra.2012.26.3811.

The risk and management of anaphylaxis in the setting of immunotherapy

Phil Lieberman  1
Affiliations
Review

The risk and management of anaphylaxis in the setting of immunotherapy

Phil Lieberman. Am J Rhinol Allergy. 2012 Nov-Dec.

Abstract

Background: Anaphylactic events due to immunotherapy are probably not completely preventable. There is always an inherent risk surrounding the administration of an allergen to an individual who is sensitized to the substance administered.

Methods: There are, however, effective measures to reduce the risk of these events, and to optimize the assurance of a good outcome in the face of such an event.

Results: Of prime importance in preventing these episodes is the regular assessment of the patient's health status, especially in regard to asthma, and the careful attention to the prevention of dosing errors.

Conclusion: Of equal importance, in regard to assuring a good outcome should such an event occur, are the rapid recognition of symptoms and the immediate injection of epinephrine, the drug of choice for the treatment of any episode of anaphylaxis.

PubMed Disclaimer

Conflict of interest statement

The author has no conflicts of interest to declare pertaining to this article

Figures

Figure 1.
Figure 1.
Algorithm for the treatment of an anaphylactic event in the outpatient setting (i.v.). (Adopted from Ref. .)
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Cox L, Nelson H, Lockey R, et al. Allergen immunotherapy: A practice parameter. J Allergy Clin Immunol 127:S1–S55, 2011. - PubMed
    1. Lieberman P, Nicklas R, Oppenheimer J, et al. The diagnosis and management of anaphylaxis practice parameter: 2010 Update. J Allergy Clin Immunol 126:477–480, 2010. - PubMed
    1. Cox L, Larenas-Linnemann D, Lockey R. Speaking the same language: The World Allergy Organization subcutaneous immunotherapy systemic reaction grading system. J Allergy Clin Immunol 125:569–574, 2010. - PubMed
    1. Blaiss MS. Allergic rhinitis: Direct and indirect costs. Allergy Asthma Proc 31:375–380, 2010. - PubMed
    1. Alzakar RH, Alsamarai AM. Efficacy of immunotherapy for treatment of allergic asthma in children. Allergy Asthma Proc 31:324–330, 2010. - PubMed