Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2012 Dec 11;16(6):185.
doi: 10.1186/cc11881.

The role of natural killer cells in the pathogenesis of sepsis: the ongoing enigma

Julia Bohannon, Yin Guo, Edward R Sherwood
Comment

The role of natural killer cells in the pathogenesis of sepsis: the ongoing enigma

Julia Bohannon et al. Crit Care. .

Abstract

The study by Souza-Fonseca-Guimaraes and colleagues in the previous issue of Critical Care shows several alterations in blood natural killer (NK) characteristics during human sepsis and systemic inflammatory response syndrome, including changes in NK cell numbers, Toll-like receptor (TLR) expression, and responsiveness to TLR agonists. This paper advances our knowledge of NK cell biology during sepsis and provides the background for future investigations.

PubMed Disclaimer

Comment on

References

    1. Souza-Fonseca-Guimaraes F, Parlato M, Philippart F, Misset B, Cavaillon JM, Adib-Conquy M. Study Group C. Toll-like receptors expression and interferon-gamma production by NK cells in human sepsis. Crit Care. 2012;16:R206. doi: 10.1186/cc11838. - DOI - PMC - PubMed
    1. Oberholzer A, Harter L, Feilner A, Steckholzer U, Trentz O, Ertel W. Differential effect of caspase inhibition on proinflammatory cytokine release in septic patients. Shock. 2000;16:253–257. doi: 10.1097/00024382-200014030-00002. discussion 7-8. - DOI - PubMed
    1. Biswas SK, Lopez-Collazo E. Endotoxin tolerance: new mechanisms, molecules and clinical significance. Trends Immunol. 2009;16:475–487. doi: 10.1016/j.it.2009.07.009. - DOI - PubMed
    1. Muenzer JT, Davis CG, Chang K, Schmidt RE, Dunne WM, Coopersmith CM, Hotchkiss RS. Characterization and modulation of the immunosuppressive phase of sepsis. Infect Immun. 2010;16:1582–1592. doi: 10.1128/IAI.01213-09. - DOI - PMC - PubMed
    1. Flohe SB, Agrawal H, Flohe S, Rani M, Bangen JM, Schade FU. Diversity of interferon gamma and granulocyte-macrophage colony-stimulating factor in restoring immune dysfunction of dendritic cells and macrophages during polymicrobial sepsis. Mol Med. 2008;16:247–256. - PMC - PubMed