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Meta-Analysis
. 2012 Dec 12;12(12):CD004796.
doi: 10.1002/14651858.CD004796.pub2.

Manipulative therapies for infantile colic

Dawn Dobson  1 , Peter L B J Lucassen, Joyce J Miller, Arine M Vlieger, Philip Prescott, George Lewith
Affiliations
Meta-Analysis

Manipulative therapies for infantile colic

Dawn Dobson et al. Cochrane Database Syst Rev. .

Abstract

Background: Infantile colic is a common disorder, affecting around one in six families, and in 2001 was reported to cost the UK National Health Service in excess of £65 million per year (Morris 2001). Although it usually remits by six months of age, there is some evidence of longer-term sequelae for both children and parents.Manipulative therapies, such as chiropractic and osteopathy, have been suggested as interventions to reduce the severity of symptoms.

Objectives: To evaluate the results of studies designed to address efficacy or effectiveness of manipulative therapies (specifically, chiropractic, osteopathy and cranial manipulation) for infantile colic in infants less than six months of age.

Search methods: We searched following databases: CENTRAL (2012, Issue 4), MEDLINE (1948 to April Week 3 2012), EMBASE (1980 to 2012 Week 17), CINAHL (1938 to April 2012), PsycINFO (1806 to April 2012), Science Citation Index (1970 to April 2012), Social Science Citation Index (1970 to April 2012), Conference Proceedings Citation Index - Science (1990 to April 2012) and Conference Proceedings Citation Index - Social Science & Humanities (1970 to April 2012). We also searched all available years of LILACS, PEDro, ZETOC, WorldCat, TROVE, DART-Europe, ClinicalTrials.gov and ICTRP (May 2012), and contacted over 90 chiropractic and osteopathic institutions around the world. In addition, we searched CentreWatch, NRR Archive and UKCRN in December 2010.

Selection criteria: Randomised trials evaluating the effect of chiropractic, osteopathy or cranial osteopathy alone or in conjunction with other interventions for the treatment of infantile colic.

Data collection and analysis: In pairs, five of the review authors (a) assessed the eligibility of studies against the inclusion criteria, (b) extracted data from the included studies and (c) assessed the risk of bias for all included studies. Each article or study was assessed independently by two review authors. One review author entered the data into Review Manager software and the team's statistician (PP) reviewed the chosen analytical settings.

Main results: We identified six studies for inclusion in our review, representing a total of 325 infants. There were three further studies that we could not find information about and we identified three other ongoing studies. Of the six included studies, five were suggestive of a beneficial effect and one found no evidence that manipulative therapies had any beneficial effect on the natural course of infantile colic. Tests for heterogeneity imply that there may be some underlying difference between this study and the other five.Five studies measured daily hours of crying and these data were combined, suggesting that manipulative therapies had a significant effect on infant colic - reducing average crying time by one hour and 12 minutes per day (mean difference (MD) -1.20; 95% confidence interval (CI) -1.89 to -0.51). This conclusion is sustained even when considering only studies with a low risk of selection bias (sequence generation and allocation concealment) (MD -1.24; 95% CI -2.16 to -0.33); those with a low risk of attrition bias (MD -1.95; 95% CI -2.96 to -0.94), or only those studies that have been published in the peer-reviewed literature (MD -1.01; 95% CI -1.78 to -0.24). However, when combining only those studies with a low risk of performance bias (parental 'blinding'), the improvement in daily crying hours was not statistically significant (MD -0.57; 95% CI -2.24 to 1.09).One study considered whether the reduction in crying time was clinically significant. This found that a greater proportion of parents of infants receiving a manipulative therapy reported clinically significant improvements than did parents of those receiving no treatment (reduction in crying to less than two hours: odds ratio (OR) 6.33; 95% CI 1.54 to 26.00; more than 30% reduction in crying: OR 3.70; 95% CI 1.15 to 11.86).Analysis of data from three studies that measured 'full recovery' from colic as reported by parents found that manipulative therapies did not result in significantly higher proportions of parents reporting recovery (OR 11.12; 95% CI 0.46 to 267.52).One study measured infant sleeping time and found manipulative therapy resulted in statistically significant improvement (MD 1.17; 95% CI 0.22 to 2.12).The quality of the studies was variable. There was a generally low risk of selection bias but only two of the six studies were evaluated as being at low risk of performance bias, three at low risk of detection bias and one at low risk of attrition bias.One of the studies recorded adverse events and none were encountered. However, with only a sample of 325 infants, we have too few data to reach any definitive conclusions about safety.

Authors' conclusions: The studies included in this meta-analysis were generally small and methodologically prone to bias, which makes it impossible to arrive at a definitive conclusion about the effectiveness of manipulative therapies for infantile colic.The majority of the included trials appeared to indicate that the parents of infants receiving manipulative therapies reported fewer hours crying per day than parents whose infants did not, based on contemporaneous crying diaries, and this difference was statistically significant. The trials also indicate that a greater proportion of those parents reported improvements that were clinically significant. However, most studies had a high risk of performance bias due to the fact that the assessors (parents) were not blind to who had received the intervention. When combining only those trials with a low risk of such performance bias, the results did not reach statistical significance. Further research is required where those assessing the treatment outcomes do not know whether or not the infant has received a manipulative therapy.There are inadequate data to reach any definitive conclusions about the safety of these interventions.

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Conflict of interest statement

Dawn Dobson ‐ financial support has been provided by the College of Chiropractors and the McTimoney Chiropractic Association for a PhD, of which this review forms a part. Neither institution has sought to influence this review in any way. Peter LBJ Lucassen ‐ none known Joyce J Miller ‐ teacher at Anglo‐European College of Chiropractic and lead tutor of MSc in Musculoskeletal Health of Paediatrics validated by Bournemouth University. She has authored or co‐authored nine articles on the topic of excessive infant crying or infant colic and co‐authored a research article (Miller 2010) that was included in this review (although she did not participate in its selection or assessment). Arine M Vlieger ‐ none known. Philip Prescott ‐ none known. George Lewith ‐ none known.

Figures

1
1
Study flow diagram
2
2
Risk of bias summary: review authors' judgements about each risk of bias item for each included study
3
3
Forest plot of comparison: 1 Manipulative therapies versus control, outcome: 1.1 Change in daily hours of crying
4
4
Forest plot of comparison: 1 Manipulative therapies versus control, outcome: 1.5 Presence/absence of colic
1.1
1.1. Analysis
Comparison 1 Manipulative therapy versus control, Outcome 1 Change in daily hours of crying.
1.2
1.2. Analysis
Comparison 1 Manipulative therapy versus control, Outcome 2 Reduction to less than two hours crying per day.
1.3
1.3. Analysis
Comparison 1 Manipulative therapy versus control, Outcome 3 Greater than 30% improvement in daily hours of crying.
1.4
1.4. Analysis
Comparison 1 Manipulative therapy versus control, Outcome 4 Presence/absence of colic.
1.5
1.5. Analysis
Comparison 1 Manipulative therapy versus control, Outcome 5 Change in mean daily hours of sleeping.
See this image and copyright information in PMC

Update of

  • doi: 10.1002/14651858.CD004796

References

References to studies included in this review

Hayden 2006 {published and unpublished data}
    1. *Hayden C, Mullinger B. A preliminary assessment of the impact of cranial osteopathy for the relief of infantile colic. Complementary Therapies in Clinical Practice 2006;12(2):83‐90. - PubMed
    1. Hayden C. Towards an Understanding of the Role of Cranial Osteopathy in the Treatment of Infantile Colic [Masters thesis]. Maidstone, UK: European School of Osteopathy, 2001.
Heber 2003 {published data only}
    1. Heber A, Senger U. [DIE OSTEOPATHISCHE BEHANDLUNGBEI3‐ MONATSKOLIK IM VERGLEICHZURKONVENTIONELLEN THERAPIE]. Osteopathic Treatment Of Infantile Colic [Masters thesis]. Germany: Akademie für Osteopathie (AFO), 2003.
Mercer 1999 {published data only}
    1. *Mercer C. A Study to Determine the Efficacy of Chiropractic Spinal Adjustments as a Treatment Protocol in the Management of Infantile Colic [Thesis]. Durban, SA: Technikon Natal, Durban University, 1999.
    1. Mercer C, Nook BC. The efficacy of chiropractic spinal adjustments as a treatment protocol in the management of infantile colic. World Federation of Chiropractic 5th Biennial Congress, 1999 May 17‐22; Auckland. Auckland, NZ, 1999:170‐1.
Miller 2010 {published and unpublished data}
    1. *Miller J, Newell D, Bolton J. Efficacy of chiropractic manual therapy in infant colic: a pragmatic single‐blind, randomised controlled trial. Journal of Manipulative and Physiological Therapeutics 2012;35(8):600‐7. [DOI: ] - PubMed
    1. Miller J. Personal communication to D. Dobson 24 April 2012.
    1. Miller J, Newell D, Bolton J. Chiropractic manual therapy for the infant with colic crying: a randomised double blind placebo‐controlled trial. Report of a floor presentation during European Chiropractors' Union Convention, London, 13‐15 May 2010. Clinical Chiropractic 2010;13(2):178‐80.
Olafsdottir 2001 {published data only}
    1. Olafsdottir E, Forshei S, Fluge G, Markestad T. Randomised controlled trial of infantile colic treated with chiropractic spinal manipulation. Archives of Disease in Childhood 2001;84(2):138‐41. - PMC - PubMed
Wiberg 1999 {published data only}
    1. Wiberg JM, Nordsteen J, Nilsson N. The short‐term effect of spinal manipulation in the treatment of infantile colic: a randomized controlled clinical trial with a blinded observer. Journal of Manipulative and Physiological Therapeutics 1999;22(8):517‐22. - PubMed

References to studies excluded from this review

Browning 2008 {published data only}
    1. Browning M, Miller J. Comparison of the short‐term effects of chiropractic spinal manipulation and occipito‐sacral decompression in the treatment of infant colic: a single‐blinded, randomised, comparison trial. Clinical Chiropractic 2008;11(3):122‐9.
Davies 2007 {published data only}
    1. Davies NJ, Jamison JR. Chiropractic management of irritable baby syndrome. Chiropractic Journal of Australia 2007;37(1):25‐9.
Denckens 1996 {unpublished data only}
    1. Denckens G. Infantile Colic: a Pilot‐Study Conducted at the ESO's Children's Clinic [Thesis]. Maidstone, UK: European School of Osteopathy, 1996.
Gludovatz 2003 {unpublished data only}
    1. Gludovatz P. [AUSWIRKUNGEN VON OSTEOPATHISCHENBEHANDLUNGEN AUF DIE DREIMONATSKOLIKENBEI SÄUGLINGEN]. Effects of Osteopathic Treatments on Infantile Colic [Thesis]. Vienna, Austria: Wiener Schule für Osteopathie, 2003.
Karpelowski 2004 {unpublished data only}
    1. Karpelowsky AS. The Efficacy of Chiropractic Spinal Manipulative Therapy in the Treatment of Infantile Colic [Thesis]. Johannesburg, SA: The University of Johannesburg, 2004.
Koonin 2002 {unpublished data only}
    1. Koonin SD. A Comparative Study to Determine the Efficacy of Chiropractic Spinal Manipulative Therapy and Allopathic Medication in the Treatment of Infantile Colic [Thesis]. Johannesburg, SA: The University of Johannesburg, 2002.
Mills 2010 {unpublished data only}
    1. Mills M. Personal communication 9 March 2012.

References to studies awaiting assessment

Furlano 2009 {published data only}
    1. Furlano RI, Sidler M. "Oh, Baby, please don't cry!" Osteopathic treatment reduces crying intensity and duration in infants with colic, compared to treatment as usual. Swiss Medical Weekly 2009;139:21‐2.
Schwan 2006 {published data only}
    1. Schwan EC, Gehlen NI. Chiropractic Treatment of Infantile Colic [Thesis]. Novo Hamburgo, Brazil: Feevale Central University, 2006.
Stolz 1995 {published data only}
    1. Stolz A. Non‐invasive natural and complementary therapies for babies with colic and gastric reflux. Australian Journal of Holistic Nursing 1995; Vol. 2, issue 2:40‐3.

References to ongoing studies

Friis 2009 {published data only}
    1. Friis K, Sanden‐Husey P. Analysis and development of a project plan for a randomised controlled trial of chiropractic treatment of infantile colic [Analys och utveckling av projektplan inför randomiserad kontrollerad prövning avseende kiropraktisk behandling av spädbarnskolik]. Study Protocol: Skandinaviska Kiropraktorhögskolan.
Hestbaek 2009 {published data only}
    1. Hesbaek L. The effect of chiropractic treatment on infantile colic: a randomized controlled trial. Clinical Protocol: Clinical Trials 2009.
Stangl {published data only}
    1. Stangl R. [Osteopathische versus Psychologische Behandlung bei Schreikinder]. Osteopathic Versus Psychological Treatment For Crying Children [Thesis]. Western States.

Additional references

AACOM
    1. American Association of Colleges of Osteopathic Medicine. Member colleges. www.aacom.org/about/colleges/Pages/default.aspx. (accessed 4 October 2012).
ACC 2010
    1. The Association of Chiropractic Colleges Members. www.chirocolleges.org/members.html. (accessed 4 October 2012).
Akman 2006
    1. Akman I, Kuscu K, Ozdemir N, Yurdakul Z, Solakoglu M, Orhan L, et al. Mothers' postpartum psychological adjustment and infantile colic. Archives of Disease in Childhood. 2006/02/03 2006; Vol. 91, issue 5:417‐9. - PMC - PubMed
Alcantara 2009
    1. Alcantara J, Ohm J, Kunz D. The safety and effectiveness of pediatric chiropractic: a survey of chiropractors and parents in a practice‐based research network. Explore 2009;5:290‐5. - PubMed
Alcantara 2011
    1. Alcantara J, Alcantara JD. The chiropractic care of infants with colic: a systematic review of the literature. Explore 2011;7(3):168‐74. - PubMed
Barr 1991
    1. Barr RG. Colic and gas. Pediatric Gastrointestinal Disease: Pathophysiology, Diagnosis and Management. Philadelphia, PA: Decker, 1991:210‐24.
Biederman 1992
    1. Biederman H. Kinematic imbalance due to suboccipital strain in newborns. Journal of Manual Medicine 1992;6:151‐6.
Biedermann 2005
    1. Biedermann H. Manual therapy in children: proposals for an etiologic model. Journal of Manipulative and Physiological Therapeutics. 2005/04/28 2005; Vol. 28, issue 3:e1‐15. - PubMed
Brand 2005
    1. Brand PLP, Engelbert RHH, Helders PJM, Offringa M. Systematic review of effects of manual therapy in infants with kinetic imbalance due to suboccipital strain (KISS) syndrome. Journal of Manual and Manipulative Therapy 2005;13(4):209‐14.
Brazelton 1962
    1. Brazelton TB. Crying in infancy. Pediatrics 1962; Vol. 29:579‐88. - PubMed
Bronfort 2010
    1. Bronfort G, Haas M, Evans R, Leiniger B, Triano J. Effectiveness of manual therapies: the UK evidence report. Chiropractic Osteopathy 2010; Vol. 18:3. - PMC - PubMed
Canivet 2000
    1. Canivet C, Jakobsson I, Hagander B. Infantile colic. Follow‐up at four years of age: still more "emotional". Acta Paediatrica 2000; Vol. 89, issue 1:13‐7. - PubMed
Carey 1984
    1. Carey WB. "Colic" ‐ primary excessive crying as an infant‐environment interaction. Pediatric Clinics of North America 1984;31:993‐1005. - PubMed
Cassidy 2009
    1. Cassidy JD, Boyle E, Côté P, He Y, Hogg‐Johnson S, Silver FL, et al. Risk of vertebrobasilar stroke and chiropractic care: results of a population‐based case‐control and case‐crossover study. Journal of Manipulative and Physiological Therapeutics 2009;32(2, Supplement 1):S201‐8. - PubMed
CCE 2010
    1. Council on Chiropractic Education. Membership of The Council on Chiropractic Education. www.cce‐usa.org/Members.html. (accessed 4 October 2012).
Colloca 2009
    1. Colloca CJ, Cunliffe C, Pinnock MH, Kim YK, Hinrichs RN. Force‐time profile characterization of the McTimoney toggle‐torque‐recoil technique. Journal of Manipulative and Physiological Therapeutics. 2009/06/23 2009; Vol. 32, issue 5:372‐8. - PubMed
Craniosacral Therapy Association of the UK 2010
    1. The Craniosacral Therapy Association of the UK. What is craniosacral therapy? www.craniosacral.co.uk/. (accessed 26 March 2010).
Deeks 2011
    1. Deeks JJ, Higgins JPT, Altman DG (editors). Chapter 9: Analysing data and undertaking meta‐analyses. In: Higgins JPT, Green S editor(s). Cochrane Handbook for Systematic Reviews of Interventions. Chichester, UK: John Wiley & Sons, 2011.
Dobson 2011
    1. Dobson D, Lewith G, Cunliffe C. What is the evidence for chiropractic management of infantile colic?. Clinical Chiropractic 2011;14(2):71‐2.
Ernst 2003
    1. Ernst E. Chiropractic manipulation for non‐spinal pain ‐ a systematic review. The New Zealand Medical Journal 2003;116:1179. - PubMed
Ernst 2009
    1. Ernst E. Chiropractic spinal manipulation for infant colic: a systematic review of randomised clinical trials. International Journal of Clinical Practice 2009; Vol. 63, issue 9:1351‐3. - PubMed
European Council on Chiropractic Education 2010
    1. European Council on Chiropractic Education. Institutions holding Accredited Status with the ECCE, 2010. www.cce‐europe.com/accredited‐institutions.html. (accessed 5 October 2012).
Garrison 2000
    1. Garrison MM, Christakis DA. Early childhood: colic, child development, and poisoning prevention: a systematic review of treatments for infant colic. Pediatrics 2000;106:184‐90. - PubMed
General Chiropractic Council 2010
    1. General Chiropractic Council. What is Chiropractic? www.gcc‐uk.org/page.cfm?page_id=4. (accessed 5 October 2012).
General Osteopathic Council 2010
    1. General Osteopathic Council. About osteopathy. www.osteopathy.org.uk/information/about‐osteopathy/. (accessed 5 October 2012).
General Osteopathic Council 2010b
    1. General Osteopathic Council. Training courses. www.osteopathy.org.uk/practice/becoming‐an‐osteopath/training‐courses/. (accessed 5 October 2012).
Gotlib 2008
    1. Gotlib A, Rupert R. Chiropractic manipulation in pediatric health conditions ‐ an updated systematic review. Chiropractic & Osteopathy 2008;16:11. - PMC - PubMed
GRADEPro 2008 [Computer program]
    1. GRADEpro. Version 3.2 for Windows. Jan Brozek, Andrew Oxman, Holger Schünemann, 2008.
Gustafson 2000
    1. Gustafson GE, Wood RM, Green JA. Can we hear the causes of infants' crying?. In: Barr RG, Hopkins B, Green JA editor(s). Crying As A Sign, A Symptom, And A Signal. London: Cambridge University Press, 2000:8‐22.
Haas 2004
    1. Haas M, Groupp E, Aickin M, Fairweather A, Ganger B, Attwood M, et al. Dose response for chiropractic care of chronic cervicogenic headache and associated neck pain: a randomized pilot study. Journal of Manipulative and Physiological Therapeutics 2004; Vol. 27, issue 9:547‐53. - PubMed
Hawk 2007
    1. Hawk C, Khorsan R, Lisi AJ, Ferrance RJ, Evans MW. Chiropractic care for nonmusculoskeletal conditions: a systematic review with implications for whole systems research. Journal of Alternative and Complementary Medicine 2007; Vol. 13, issue 5:491‐512. - PubMed
Higgins 2002
    1. Higgins JP, Thompson SG. Quantifying heterogeneity in a meta‐analysis. Statistics in Medicine 2002;21:1539‐58. - PubMed
Higgins 2008
    1. Higgins JPT, Altman DG (editors). Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green D editor(s). Cochrane Handbook for Systematic Reviews of Interventions. Chichester, UK: John Wiley & Sons, 2008.
Higgins 2008b
    1. Higgins JPT, Deeks JJ, Altman DG (editors). Chapter 16: Special topics in statistics. In: Higgins JPT, Green S editor(s). Cochrane Handbook for Systematic Reviews of Interventions. Chichester, UK: John WIley & Sons, 2008.
Hill 2000
    1. Hill D, Hosking C. Infantile colic and food hypersensitivity. Journal of Pediatric Gastroenterology and Nutrition 2000; Vol. 30:S67‐76. - PubMed
Hipperson 2004
    1. Hipperson AJ. Chiropractic management of infantile colic. Clinical Chiropractic 2004; Vol. 7, issue 4:180‐6.
Holla 2009
    1. Holla M, Ijland MM, Vliet AM, Edwards M, Verlaat CW. Diseased infant after 'craniosacral' manipulation of the neck and spine [Overleden zuigeling na 'craniosacrale' manipulatie van hals en wervelkolom]. Nederlands Tijdschrift Voor Geneeskunde 2009;153(17):828‐31. - PubMed
Hughes 2002
    1. Hughes S, Bolton J. Is chiropractic an effective treatment in infantile colic?. Archives of Disease in Childhood 2002;86(5):382‐4. - PMC - PubMed
Husereau 2003
    1. Husereau D, Clifford T, Aker PD, Leduc D, Mensinkai S. Spinal Manipulation For Infantile Colic. Technology Report no 42. Ottawa, Canada: Canadian Co‐ordinating Office for Health and Technology Assessment, 2003.
Iacono 2005
    1. Iacono G, Merolla R, D'Amico D, Bonci E, Cavataio F, Prima L, et al. Gastrointestinal symptoms in infancy: a population‐based prospective study. Digestive and Liver Disease 2005;37(6):432‐8. - PubMed
Illingworth 1985
    1. Illingworth R. Infantile colic revisited. Archives of Disease in Childhood 1985;60:981‐5. - PMC - PubMed
Kanabar 2001
    1. Kanabar D, Randhawa M, Clayton P. Improvement of symptoms in infant colic following reduction of lactose load with lactase. Journal of Human Nutrition and Dietetics 2001; Vol. 14, issue 5:359‐63. - PubMed
Kawchuk 1992
    1. Kawchuk GN, Herzog W, Hasler EM. Forces generated during spinal manipulative therapy of the cervical spine: a pilot study. Journal of Manipulative and Physiological Therapeutics. 1992/06/01 1992; Vol. 15, issue 5:275‐8. - PubMed
Kawchuk 1993
    1. Kawchuk GN, Herzog W. Biomechanical characterization (fingerprinting) of five novel methods of cervical spine manipulation. Journal of Manipulative and Physiological Therapeutics. 1993/11/01 1993; Vol. 16, issue 9:573‐7. - PubMed
Kirjavainen 2001
    1. Kirjavainen J, Jahnukainen T, Huhtala V, Lehtonen L, Kirjavainen T, Korvenranta H, et al. The balance of the autonomic nervous system is normal in colicky infants. Acta Paediatrica 2001; Vol. 90, issue 3:250‐4. - PubMed
Klougart 1989
    1. Klougart N, Nilsson N, Jacobsend J. Infantile colic treated by chiropractors: a prospective study of 316 cases. Journal of Manipulative and Physiological Therapeutics 1989;12:281. - PubMed
Lee 2007
    1. Lee C, Barr RG, Catherine N, Wicks A. Age‐related incidence of publicly reported shaken baby syndrome cases: is crying a trigger for shaking?. Journal of Developmental and Behavioral Pediatrics 2007; Vol. 28, issue 4:288‐93. - PubMed
Lefebvre 2008
    1. Lefebvre C, Manheimer E, Glanville J. Chapter 6: Searching for studies. In: Higgins JPT, Green, S editor(s). Cochrane Handbook for Systematic Reviews of Interventions. Chichester, UK: John Wiley & Sons, 2008.
Lehtonen 1994
    1. Lehtonen L, Korvenranta H, Eerola E. Intestinal microflora in colicky infants: bacterial cultures and gas‐liquid chromatography. Journal of Pediatric Gastroenterology and Nutrition 1994; Vol. 19, issue 3:310‐4. - PubMed
Lester 1992
    1. Lester BM, Boukydis CFZ, Garcia‐Coll CT, Hole WT, Peucker M. Infantile colic: acoustic cry characteristics, maternal perception of cry, and temperament. Infant Behavior and Development 1992; Vol. 15, issue 1:15‐26.
Lindberg 1999
    1. Lindberg T. Infantile colic and small intestinal function: a nutritional problem?. Acta Paediatrica Supplement 1999; Vol. 88, issue 430:58‐60. - PubMed
Lucassen 1998
    1. Lucassen PL, Assebdekft WJ, Gubbels JW, Eijk JT, Geldrop WJ, Neven AK. Effectiveness of treatments for infantile colic: systematic review. BMJ 1998;318:1563‐9. - PMC - PubMed
Lucassen 2001
    1. Lucassen PL, Assendelft EJ, Eijk JT, Gubbels JW, Douwes AC, Geldrop WJ. Systematic review of the occurrence of infantile colic in the community. Archives of Disease in Childhood 2001;84(5):398‐403. - PMC - PubMed
Lucassen 2003
    1. Lucassen PLBJ, Assendelft WJJ, Geldrop WJ. Elimination of cows' milk protein from infant diet for the treatment of infantile colic. Cochrane Database of Systematic Reviews 2003, Issue 4. [DOI: 10.1002/14651858.CD004533] - DOI
Lucassen 2010
    1. Lucassen, PLBJ. Colic in infants. Clinical Evidence (Online) 2010;Feb 5. - PMC - PubMed
McTimoney 2010
    1. McTimoney Chiropractic Association. What is Chiropractic, and How Does it Work? www.mctimoneychiropractic.org/. (accessed 5 October 2012).
McTimoney College of Chiropractic 2010
    1. McTimoney College of Chiropractic. MSc Chiropractic (Paediatrics) www.mctimoney‐college.ac.uk/courses‐cpd/msc‐chiropractic‐paediatrics/. (accessed 5 October 2012).
Miller 1991
    1. Miller AR, Barr RG. Infantile colic. Is it a gut issue?. Pediatric Clinics of North America 1991;38:1407‐23. - PubMed
Miller 2007
    1. Miller J. Cry‐babies: a framework for chiropractic care. Clinical Chiropractic 2007; Vol. 10:139‐46.
Miller‐Loncar 2004
    1. Miller‐Loncar C, Bigsby R, High P, Wallach M, Lester B. Infant colic and feeding difficulties. Archives of Diseases in Childhood 2004;89(10):908‐12. - PMC - PubMed
Morris 2001
    1. Morris S, James‐Roberts IS, Sleep J, Gillham P. Economic evaluation of strategies for managing crying and sleeping problems. Archives of Disease in Childhood 2001;84(1):15‐9. - PMC - PubMed
Neu 2003
    1. Neu M, Robinson J. Infants with colic: their childhood characteristics. Journal of Pediatric Nursing 2003; Vol. 18, issue 1:12‐20. - PubMed
Nilsson 1985
    1. Nilsson N. Infantile colic and chiropractic. European Journal of Chiropractic 1985;33:264‐5.
Osteopathic International Alliance 2010
    1. Osteopathic International Alliance. OIA membership list. www.oialliance.org/members.htm. (accessed 5 October 2012).
Overpeck 1998
    1. Overpeck MD, Brenner RA, Trumble AC, Trifiletti LB, Berendes HW. Risk factors for infant homicide in the United States. New England Journal of Medicine 1998; Vol. 339, issue 17:1211‐6. - PubMed
Paradise 1966
    1. Paradise JL. Maternal and other factors in the etiology of infantile colic. Journal of the American Medical Association 1966;197(3):123‐31. - PubMed
Peterson 2002
    1. Peterson D, Bergmann TF. Chiropractic Technique: Principles and Procedures. Philadelphia, PA: Mosby, 2002.
Pinyerd 1989
    1. Pinyerd BJ, Zipf WB. Colic: idiopathic, excessive, infant crying. Journal of Pediatric Nursing 1989;4(3):147‐61. - PubMed
Proctor 2006
    1. Proctor ML, Hing W, Johnson TC, Murphy PA. Spinal manipulation for primary and secondary dysmenorrhoea. Cochrane Database of Systematic Reviews 2006, Issue 3. [DOI: 10.1002/14651858.CD002119.pub3] - DOI - PMC - PubMed
Rao 2004
    1. Rao MR, Brenner RA, Schisterman EF, Vik T, Mills JL. Long term cognitive development in children with prolonged crying. Archives of Disease in Childhood 2004; Vol. 89, issue 11:989‐92. - PMC - PubMed
Reijneveld 2002
    1. Reijneveld SA, Brugman E, Hirasing RA. Excessive infant crying: definitions determine risk groups. Archives of Disease in Childhood 2002;87(1):43‐4. - PMC - PubMed
Reijneveld 2004
    1. Reijneveld SA, Wal MF, Brugman E, Sing RA, Verloove‐Vanhorick SP. Infant crying and abuse. The Lancet 2004; Vol. 364, issue 9442:1340‐2. - PubMed
RevMan 2011 [Computer program]
    1. The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.1. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2011.
Rhoads 2009
    1. Rhoads JM, Fatheree NY, Norori J, Liu Y, Lucke JF, Tyson JE, et al. Altered fecal microflora and increased fecal calprotectin in infants with colic. The Journal of Pediatrics 2009;155(6):823‐8. - PubMed
Savino 2004
    1. Savino F, Cresi F, Pautasso S, Palumeri E, Tullio V, Roana J. Intestinal microflora in breastfed colicky and non‐colicky infants. Acta Paediatrica 2004; Vol. 93:825‐9. - PubMed
Savino 2005
    1. Savino F, Bailo E, Oggero R, Tullio V, Roana J, Carlone N. Bacterial counts of intestinal Lactobacillus species in infants with colic. Pediatric Allergy and Immunology 2005; Vol. 16:72‐5. - PubMed
Savino 2007
    1. Savino F. Focus on infantile colic. Acta Paediatrica 2007;96:1259‐64. - PubMed
Savino 2009
    1. Savino F, Cordisco L, Tarasco V, Calabrese R, Palumeri E, Matteuzzi D. Molecular identification of coliform bacteria from colicky breastfed infants. Acta Pædiatrica 2009;98(10):1582‐8. - PubMed
Schunemann 2008
    1. Schunemann HJ, Oxman AD, Vist GE, HIggins JPT, Deeks JJ, Glasziou P, Guyatt GH. Chapter 12: Interpreting results and drawing conclusions. In: Higgins JPT, Green S editor(s). Cochrane Handbook for Systematic reviews of Interventions. Chichester (UK): John Wiley & Sons, 2008.
Smith 2003
    1. Smith WS, Johnston SC, Skalabrin EJ, Weaver M, Azari P, Albers GW, et al. Spinal manipulative therapy is an independent risk factor for vertebral artery dissection. Neurology 2003;60(9):1424‐8. - PubMed
Soltis 2004
    1. Soltis J. The signal functions of early infant crying. Behavioral and Brain Sciences 2004; Vol. 27, issue 4:443‐58. - PubMed
St James‐Roberts 1991
    1. James‐Roberts I. Persistent infant crying. Archives of Disease in Childhood 1991;66:653‐5. - PMC - PubMed
St James‐Roberts 1991b
    1. James‐Roberts I, Halil AT. Infant crying patterns in the first year: normal community and clinical findings. Journal of Child Psychology and Psychiatry 1991; Vol. 32:951‐68. - PubMed
Stahlberg 1984
    1. Stahlberg MR. Infantile colic: occurrence and risk factors. European Journal of Pediatrics 1984;143(2):108‐11. - PubMed
Sterne 2008
    1. Sterne JAC, Egger M, Moher D (editors). Chapter 10: Addressing reporting biases. In: Higgins JPT, Green S editor(s). Cochrane Handbook for Systematic Reviews of Interventions. Chichester, UK: John Wiley & Sons, 2008.
Still 1910
    1. Still AT. Osteopathy Research and Practice. Kirksville, MO: Self‐published, 1910.
Sutherland Society 2010
    1. The Sutherland Society. Cranial osteopathy for babies and children. www.cranial.org.uk/page3.html. (accessed 5 October 2012).
Treem 1994
    1. Treem WR. Infant colic. A pediatric gastroenterologist's perspective. Pediatric Clinics of North America 1994;41:1121‐38. - PubMed
Underdown 2006
    1. Underdown A, Barlow J, Chung V, Stewart‐Brown S. Massage intervention for promoting mental and physical health in infants aged under six months. Cochrane Database of Systematic Reviews 2006, Issue 4. [DOI: 10.1002/14651858.CD005038.pub2] - DOI - PubMed
Vohra 2007
    1. Vohra S, Johnston BC, Cramer K, Humphreys K. Adverse events associated with pediatric spinal manipulation: a systematic review. Pediatrics 2007;119(1):e275‐83. - PubMed
Wessel 1954
    1. Wessel MA, Cobb JC, Jackson EB, Harris GS, Detwilter BA. Paroxysmal fussing in infancy, sometimes called "colic". Pediatrics 1954;14(5):421‐33. - PubMed
White 2012
    1. White P, Bishop FL, Prescott P, Scott C, Little P, Lewith G. Practice, practitioner, or placebo? A multifactorial, mixed‐methods randomized controlled trial of acupuncture. Pain 2012;153(2):455‐62. - PubMed
Wikipedia 2010
    1. Wikipedia. List of chiropractic schools. en.wikipedia.org/wiki/List_of_chiropractic_schools. (accessed 5 October 2012).
Wikipedia 2010b
    1. Anon. List of osteopathic colleges. en.wikipedia.org/wiki/List_of_osteopathic_colleges. (accessed 5 October 2012).

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