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. 2013 Apr 1;73(7):679-82.
doi: 10.1016/j.biopsych.2012.10.030. Epub 2012 Dec 11.

Contribution of common genetic variants to antidepressant response

Katherine E Tansey  1 , Michel Guipponi, Xiaolan Hu, Enrico Domenici, Glyn Lewis, Alain Malafosse, Jens R Wendland, Cathryn M Lewis, Peter McGuffin, Rudolf Uher
Affiliations

Contribution of common genetic variants to antidepressant response

Katherine E Tansey et al. Biol Psychiatry. .

Abstract

Background: Pharmacogenetic studies aiming to personalize the treatment of depression are based on the assumption that response to antidepressants is a heritable trait, but there is no compelling evidence to support this.

Methods: We estimate the contribution of common genetic variation to antidepressant response with Genome-Wide Complex Trait Analysis in a combined sample of 2799 antidepressant-treated subjects with major depressive disorder and genome-wide genotype data.

Results: We find that common genetic variants explain 42% (SE = .180, p = .009) of individual differences in antidepressant response.

Conclusions: These results suggest that response to antidepressants is a complex trait with substantial contribution from a large number of common genetic variants of small effect.

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Comment in

  • Antidepressant response and polygenes.
    Purcell SM. Purcell SM. Biol Psychiatry. 2013 Apr 1;73(7):600-1. doi: 10.1016/j.biopsych.2013.01.023. Biol Psychiatry. 2013. PMID: 23497743 No abstract available.

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