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Review
. 2012 Dec 14:11:109.
doi: 10.1186/1475-2891-11-109.

Dietary biomarkers: advances, limitations and future directions

Valisa E Hedrick  1 , Andrea M Dietrich, Paul A Estabrooks, Jyoti Savla, Elena Serrano, Brenda M Davy
Affiliations
Review

Dietary biomarkers: advances, limitations and future directions

Valisa E Hedrick et al. Nutr J. .

Abstract

The subjective nature of self-reported dietary intake assessment methods presents numerous challenges to obtaining accurate dietary intake and nutritional status. This limitation can be overcome by the use of dietary biomarkers, which are able to objectively assess dietary consumption (or exposure) without the bias of self-reported dietary intake errors. The need for dietary biomarkers was addressed by the Institute of Medicine, who recognized the lack of nutritional biomarkers as a knowledge gap requiring future research. The purpose of this article is to review existing literature on currently available dietary biomarkers, including novel biomarkers of specific foods and dietary components, and assess the validity, reliability and sensitivity of the markers. This review revealed several biomarkers in need of additional validation research; research is also needed to produce sensitive, specific, cost-effective and noninvasive dietary biomarkers. The emerging field of metabolomics may help to advance the development of food/nutrient biomarkers, yet advances in food metabolome databases are needed. The availability of biomarkers that estimate intake of specific foods and dietary components could greatly enhance nutritional research targeting compliance to national recommendations as well as direct associations with disease outcomes. More research is necessary to refine existing biomarkers by accounting for confounding factors, to establish new indicators of specific food intake, and to develop techniques that are cost-effective, noninvasive, rapid and accurate measures of nutritional status.

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Figures

Figure 1
Figure 1
Flow diagram of the structured review of dietary biomarkers.
See this image and copyright information in PMC

References

    1. Frobisher C, Maxwell SM. The estimation of food portion sizes: a comparison between using descriptions of portion sizes and a photographic food atlas by children and adults. J Hum Nutr Diet. 2003;16:181–188. doi: 10.1046/j.1365-277X.2003.00434.x. - DOI - PubMed
    1. Monsen ER. Research Successful Approaches. 2. Chicago, IL: American Dietetic Association; 2003. pp. 1–482.
    1. Thompson FE, Subar AF, Loria CM, Reedy JL, Baranowski T. Need for technological innovation in dietary assessment. J Am Diet Assoc. 2010;110:48–51. doi: 10.1016/j.jada.2009.10.008. - DOI - PMC - PubMed
    1. Willett W, Lenart E. In: Nutritional epidemiology. 2. Willett W, editor. New York, NY: Oxford University Press; 1998. Reproducibility and validity of food-frequency questionnaires; pp. 101–147.
    1. Marshall TA, Eichenberger Gilmore JM, Broffitt B, Levy SM, Stumbo PJ. Relative validation of a beverage frequency questionnaire in children ages 6 months through 5 years using 3-day food and beverage diaries. J Am Diet Assoc. 2003;103:714–720. doi: 10.1053/jada.2003.50137. - DOI - PubMed