Comment on

• A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice.

  Huh D, Leslie DC, Matthews BD, Fraser JP, Jurek S, Hamilton GA, Thorneloe KS, McAlexander MA, Ingber DE. Huh D, et al. Sci Transl Med. 2012 Nov 7;4(159):159ra147. doi: 10.1126/scitranslmed.3004249. Sci Transl Med. 2012. PMID: 23136042 Free PMC article.
• An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure.

  Thorneloe KS, Cheung M, Bao W, Alsaid H, Lenhard S, Jian MY, Costell M, Maniscalco-Hauk K, Krawiec JA, Olzinski A, Gordon E, Lozinskaya I, Elefante L, Qin P, Matasic DS, James C, Tunstead J, Donovan B, Kallal L, Waszkiewicz A, Vaidya K, Davenport EA, Larkin J, Burgert M, Casillas LN, Marquis RW, Ye G, Eidam HS, Goodman KB, Toomey JR, Roethke TJ, Jucker BM, Schnackenberg CG, Townsley MI, Lepore JJ, Willette RN. Thorneloe KS, et al. Sci Transl Med. 2012 Nov 7;4(159):159ra148. doi: 10.1126/scitranslmed.3004276. Sci Transl Med. 2012. PMID: 23136043