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. 2013 Jan;14(1):1-5.
doi: 10.1038/ni.2480.

Antibody gene transfer for HIV immunoprophylaxis

Alejandro B Balazs  1 , Anthony P West Jr
Affiliations

Antibody gene transfer for HIV immunoprophylaxis

Alejandro B Balazs et al. Nat Immunol. 2013 Jan.

Abstract

Antibody gene transfer, which involves the delivery of genes that encode potent, broadly neutralizing antibodies to human immunodeficiency virus (HIV), is a promising new strategy for preventing HIV infection. A satellite symposium at the AIDS Vaccine 2012 conference brought together many of the groups working in this field.

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Figures

Figure 1
Figure 1. Comparison of prophylaxis approaches
Traditional vaccines work by engaging the adaptive immune system to produce a response that recognizes the administered antigen. Vectored immunoprophylaxis employs a viral vector, such as Adeno-Associated Virus (AAV), to deliver the genes encoding for a given antibody into muscle cells that express the desired antibodies - and secrete them into the circulation – without employing the immune system. Adapted from an illustration prepared by La Vanguardia, Barcelona.
See this image and copyright information in PMC

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