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Comparative Study
. 2014 Mar;35(3):779-91.
doi: 10.1002/hbm.22213. Epub 2012 Dec 14.

Amyloid and its association with default network integrity in Alzheimer's disease

Sofie M Adriaanse  1 , Ernesto J Sanz-Arigita, Maja A A Binnewijzend, Rik Ossenkoppele, Nelleke Tolboom, Daniëlle M E van Assema, Alle Meije Wink, Ronald Boellaard, Maqsood Yaqub, Albert D Windhorst, Wiesje M van der Flier, Philip Scheltens, Adriaan A Lammertsma, Serge A R B Rombouts, Frederik Barkhof, Bart N M van Berckel
Affiliations
Comparative Study

Amyloid and its association with default network integrity in Alzheimer's disease

Sofie M Adriaanse et al. Hum Brain Mapp. 2014 Mar.

Abstract

The purpose of this study was to investigate the association between functional connectivity and β-amyloid depositions in the default mode network (DMN) in Alzheimer's disease (AD), patients with mild cognitive impairment (MCI), and healthy elderly. Twenty-five patients with AD, 12 patients with MCI, and 18 healthy controls were included in the study. Resting-state functional magnetic resonance imaging was used to assess functional connectivity in the DMN. In parallel, amyloid burden was measured in the same subjects using positron emission tomography with carbon-11-labeled Pittsburgh Compound-B as amyloid tracer. Functional connectivity of the DMN and amyloid deposition within the DMN were not associated across all subjects or within diagnostic groups. Longitudinal studies are needed to examine if amyloid depositions precede aberrant functional connectivity in the DMN.

Keywords: Alzheimer disease; amyloid; default mode network; magnetic resonance imaging; mild cognitive impairment; positron emission tomography; resting-state fMRI.

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Figures

Figure 1
Figure 1
Voxelwise differences of functional connectivity within the DMN between groups were explored (uncorrected P < 0.01). Differences between groups are shown in red and yellow and are overlaid on the group DMN shown in blue. Patients with AD show decreased functional connectivity of the DMN when compared with healthy controls (A). Patients with AD show decreased functional connectivity of the DMN when compared with patients with MCI (B). PIB+ subjects showed decreased functional connectivity of the DMN when compared with PIB− subjects (C). The results are displayed on standard space (MNI152), 2 mm resolution, and radiological orientation. MNI coordinates are reported in the left upper corner of the figures.
Figure 2
Figure 2
Multiple regression analysis of average [11C]PIB binding in the default mode network (DMN) with voxelwise functional connectivity of the DMN (uncorrected P < 0.001) was examined across subjects (A), across subjects with exclusion of PIB− MCI patients (B), and within PIB− subjects (C), correcting for age, sex, and normalized gray matter volume (extra correction for clinical diagnosis in PIB subjects). Significant associations are plotted in red (uncorrected P < 0.001) on top of the blue group DMN mask on 2‐mm MNI152 space. MNI coordinates are reported in the left upper corner of the figures.
Figure 3
Figure 3
This scatter plot represents the association of functional connectivity of the DMN (y‐axis) with amyloid load in the DMN (x‐axis) for each subject. No correction for age, gender, or NGMV is performed in this graph. Patients with MCI who converted to AD after 1 year are represented by a box with the text “yes.”
See this image and copyright information in PMC

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