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. 2014 Jan;26(1):77-84.
doi: 10.1177/1010539512469249. Epub 2012 Dec 13.

Molecular epidemiology of Mycobacterium tuberculosis in the United States-Affiliated Pacific Islands

Sapna Bamrah  1 , Edward Desmond, Smita Ghosh, Anne Marie France, J Steve Kammerer, Lauren S Cowan, Andrew Heetderks, Alstead Forbes, Patrick K Moonan
Affiliations

Molecular epidemiology of Mycobacterium tuberculosis in the United States-Affiliated Pacific Islands

Sapna Bamrah et al. Asia Pac J Public Health. 2014 Jan.

Abstract

The United States-Affiliated Pacific Islands (USAPI) are part of the US National Tuberculosis (TB) Surveillance System and use laboratory services contracted through a cooperative agreement with the Centers for Disease Control and Prevention (CDC). In 2004, the CDC established the National Tuberculosis Genotyping Service, a system to genotype 1 isolate from each culture-confirmed case of TB. To describe the molecular epidemiology of TB in the region, we examined all Mycobacterium tuberculosis isolates submitted for genotyping from January 1, 2004, to December 31, 2008. Over this time period, the USAPI jurisdictions reported 1339 verified TB cases to the National Tuberculosis Surveillance System. Among 419 (31%) reported culture-confirmed TB cases, 352 (84%) had complete genotype results. Routine TB genotyping allowed, for the first time, an exploration of the molecular epidemiology of TB in the USAPI.

Keywords: Pacific Islands (trust territory); genotype; molecular epidemiology; tuberculosis.

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Conflict of interest statement

Declaration of Conflicting Interests

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Also, the findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.

Figures

Figure 1.
Figure 1.
Number of genotyped isolates in each jurisdiction by year—USAPI, 2004–2008.
Figure 2.
Figure 2.
Number of surveillance records, culture-confirmed cases, and genotyped isolates, 2004–2008.
See this image and copyright information in PMC

References

    1. Department of Interior, US Government. Compact of free association. http://www.fsmlaw.org/compact/index.htm. Accessed November 15, 2012.
    1. Centers for Disease Control and Prevention. Reported TB in the United States, 2009. Atlanta, GA: US Department of Health and Human Services; 2010.
    1. World Health Organization. 2010. Global Plan to Stop TB 2006–2015. http://whqlibdoc.who.int/publications/2006/924159487X_eng.pdf. Accessed November 15, 2012.
    1. Centers for Disease Control and Prevention. New CDC program for rapid genotyping of Mycobacterium tuberculosis isolates. MMWR Morb Mortal Wkly Rep. 2005;54(2):47.
    1. Clark CM, Driver CR, Munsiff SS, et al. Universal genotyping in tuberculosis control program, New York City, 2001–2003. Emerg Infect Dis. 2006;12:719–724. - PMC - PubMed

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