Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Mar;43(3):253-8.
doi: 10.7164/antibiotics.43.253.

LL-D49194 antibiotics, a novel family of antitumor agents: taxonomy, fermentation and biological properties

W M Maiese  1 , D P Labeda, J Korshalla, N Kuck, A A Fantini, M J Wildey, J Thomas, M Greenstein
Affiliations
Free article

LL-D49194 antibiotics, a novel family of antitumor agents: taxonomy, fermentation and biological properties

W M Maiese et al. J Antibiot (Tokyo). 1990 Mar.
Free article

Abstract

A novel family of antitumor antibiotics, designated LL-D49194, was isolated from the fermentation broth of an actinomycete strain identified as Streptomyces vinaceus-drappus. LL-D49194 alpha 1 and beta 2 were active against Gram-positive and inactive against Gram-negative bacteria in vitro. The beta 1 component was not active against either Gram-positive or Gram-negative bacteria. These antibiotics exhibited significant in vivo activities against several murine tumors, albeit with differing potencies.

PubMed Disclaimer

MeSH terms