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. 2013 Feb;28(1):54-61.
doi: 10.1177/1533317512467680. Epub 2012 Dec 12.

Histone deacetylases enzyme, copper, and IL-8 levels in patients with Alzheimer's disease

Mohamad A Alsadany  1 , Hanan H Shehata, Magda I Mohamad, Riham G Mahfouz
Affiliations

Histone deacetylases enzyme, copper, and IL-8 levels in patients with Alzheimer's disease

Mohamad A Alsadany et al. Am J Alzheimers Dis Other Demen. 2013 Feb.

Erratum in

  • Corrigendum.
    [No authors listed] [No authors listed] Am J Alzheimers Dis Other Demen. 2018 Nov;33(7):490. doi: 10.1177/1533317518786149. Epub 2018 Jul 9. Am J Alzheimers Dis Other Demen. 2018. PMID: 29986600 Free PMC article. No abstract available.

Abstract

Background: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive loss of cognitive abilities. Epigenetic modification, oxidative stress, and inflammation play an important role in the pathogenesis of the disease. We aimed to detect noninvasive peripheral biomarkers with a high degree of sensitivity and specificity in diagnosis and progression of AD.

Methods: A total of 25 elderly patients with AD and 25 healthy control participants were selected and subjected to cognitive assessment and laboratory measures including histone deacetylases (HDACs), copper, and interleukin 8 (IL-8) levels.

Results: The levels of HDACs, copper, and IL-8 were significantly higher in patients with AD (P < .001) and had a significant negative effect on all cognitive assessment tests. Receiver-operating curve (ROC) analysis revealed that HDACs and copper levels had higher sensitivity and specificity.

Conclusions: Plasma levels of HDACs and copper may be used as peripheral biomarkers in diagnosis of AD, while IL-8 level could be a useful biomarker in following AD progression.

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Conflict of interest statement

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Comparison in cognitive assessment between moderate and severe AD patients.
Figure 2.
Figure 2.
Comparison in laboratory measures between moderate and severe AD patients.
Figure 3.
Figure 3.
ROC (Receiver operating curve) analysis of Laboratory measures.
See this image and copyright information in PMC

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