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. 2013 May;40(5):768-78.
doi: 10.1007/s00259-012-2310-x. Epub 2012 Dec 15.

Value of ¹³¹I SPECT/CT for the evaluation of differentiated thyroid cancer: a systematic review of the literature

Yan-Li Xue  1 , Zhong-Ling Qiu, Hong-Jun Song, Quan-Yong Luo
Affiliations

Value of ¹³¹I SPECT/CT for the evaluation of differentiated thyroid cancer: a systematic review of the literature

Yan-Li Xue et al. Eur J Nucl Med Mol Imaging. 2013 May.

Abstract

Purpose: In the present study, we performed a systematic review of the current literature to assess the incremental value of (131)I single photon emission computed tomography (SPECT)/CT for the management of patients with differentiated thyroid cancer (DTC).

Methods: The search of PubMed/MEDLINE and EMBASE databases to identify studies and reference lists for articles was conducted using the terms "SPECT or SPECT/CT or SPECT-CT or single photon emission computed tomography/computed tomography and thyroid carcinoma or thyroid cancer." Studies reporting the clinical value of (131)I SPECT/CT were selected. All studies included were assessed with the Quality Assessment of Diagnostic Accuracy Studies-2 tool (QUADAS-2). Two independent reviewers selected the studies, summarized and tabulated the data, and pooled estimates were obtained. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed.

Results: A total of 14 studies involving 1,066 patients met the inclusion criteria. Data obtained included the impact of (131)I SPECT/CT on staging or risk classification (three studies), diagnostic accuracy (six studies), and follow-up (five studies).

Conclusion: Integrated SPECT/CT is a useful tool for the diagnosis, staging, risk stratification, and follow-up of DTC. The impact of (131)I SPECT/CT on the management of patients with thyroid cancer was evaluated.

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References

    1. J Nucl Med. 2001 Jul;42(7):998-1004 - PubMed
    1. J Nucl Med. 2003 Dec;44(12):1905-10 - PubMed
    1. JAMA. 2006 May 10;295(18):2164-7 - PubMed
    1. J Nucl Med. 2012 May;53(5):754-64 - PubMed
    1. Nucl Med Commun. 1993 May;14(5):365-72 - PubMed

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