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. 2012 Dec;58(12):1346-9.

Myasthenia gravis during pregnancy

Shahnaz Akhtar Chaudhry  1 , Biruthvie Vignarajah, Gideon Koren
Affiliations

Myasthenia gravis during pregnancy

Shahnaz Akhtar Chaudhry et al. Can Fam Physician. 2012 Dec.

Abstract
in English, French

Question: One of my patients who has been diagnosed with myasthenia gravis (MG) is planning pregnancy. Her MG is controlled with medications. Can her condition or her medications adversely affect her pregnancy?

Answer: The course of MG during pregnancy is unpredictable, but there is no evidence that MG can adversely affect pregnancy outcomes. Examination of most of the medications used for symptom control has so far shown reassuring results. Prepregnancy thymectomy might decrease the need for medications during pregnancy. The newborn should be carefully monitored for signs of transitory MG.

Question Une de mes patientes a reçu un diagnostic de myasthénie grave (MG) et elle planifie une grossesse. Sa MG est contrôlée par pharmacothérapie. Son état ou ses médicaments peuvent-ils avoir des effets défavorables sur sa grossesse?

Réponse L’évolution de la MG durant la grossesse est imprévisible, mais il n’existe pas de données probantes à l’effet que la MG puisse influencer négativement l’issue de la grossesse. Les résultats des études sur la plupart des médicaments utilisés pour le contrôle des symptômes sont jusqu’à présent rassurants. Une thymectomie avant la grossesse pourrait réduire la nécessité de prendre des médicaments durant la grossesse. Il faudra surveiller attentivement le nouveau-né pour détecter tout signe de MG transitoire.

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