[5-Bromodeoxyuridine inhibition of the transformation of Rous sarcoma virus-infected chicken cells]
[Article in
French]
- PMID: 232429
Item in Clipboard
[5-Bromodeoxyuridine inhibition of the transformation of Rous sarcoma virus-infected chicken cells]
[Article in
French]
C R Seances Acad Sci D.
.
Abstract
The transformation of Rous-Sarcoma-Virus-infected synchronized Chicken cells is prevented when 5-bromodeoxyuridine is added for 3 hrs. at time of the peak of the first S phase following infection. Virus progeny is normally released. The inhibitory effect of BrdU is reversed by simultaneous addition of thymidine, but not by that of deoxyuridine. Hence, the inhibition of the transformation seems to result from the incorporation of the analogue into the nuclear DNA.
Similar articles
-
Biology of Rous sarcoma virus adapted for replication and transformation of duck cells.Folia Biol (Praha). 1992;38(1):48-56. Folia Biol (Praha). 1992. PMID: 1317804
-
[Changes, during a synchronous cell cycle, of the level of incorporation of 5-bromodeoxyuridine into DNA of chick embryo fibroblasts].C R Seances Acad Sci III. 1982 Sep 20;295(2):69-72. C R Seances Acad Sci III. 1982. PMID: 6816402 French.
-
Localization of provirus DNA of Rous sarcoma virus in the DNA of infected, transformed and tumour cells of chickens.Folia Biol (Praha). 1983;29(3):221-9. Folia Biol (Praha). 1983. PMID: 6307764
-
Recombinant Rous sarcoma virus vectors for avian cells.Methods Cell Biol. 1994;43 Pt A:79-97. doi: 10.1016/s0091-679x(08)60599-3. Methods Cell Biol. 1994. PMID: 7529868 Review. No abstract available.
-
Gene delivery into the chicken embryo by using replication-competent retroviral vectors.Fukushima J Med Sci. 2004 Dec;50(2):37-46. doi: 10.5387/fms.50.37. Fukushima J Med Sci. 2004. PMID: 15779569 Review.