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Comment
. 2012 Dec 26;109(52):21184-5.
doi: 10.1073/pnas.1219534110. Epub 2012 Dec 14.

Converging on a mechanism for choline degradation

Christopher J Thibodeaux  1 , Wilfred A van der Donk
Affiliations
Comment

Converging on a mechanism for choline degradation

Christopher J Thibodeaux et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Scheme 1.
Scheme 1.
Mechanistic similarities in the catabolism of choline, ethanolamine, and glycerol; in each case, the bonds highlighted in red are cleaved by enzyme-mediated radical chemistry that results in a 1,2-migration.
Scheme 2.
Scheme 2.
Putative chemical mechanism of ethanolamine degradation by the adenosylcobalamin-dependent enzyme, ethanolamine ammonia lyase (EAL).
Scheme 3.
Scheme 3.
Putative chemical mechanisms of choline degradation by the glycyl radical enzyme, choline trimethylamine lyase (CutC). Amino acids are numbered according to their positions in CutC from D. desulfuricans.
See this image and copyright information in PMC

Comment on

References

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