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Comment
. 2013 Mar;56(6):901-3.
doi: 10.1093/cid/cis1048. Epub 2012 Dec 14.

Glucocorticosteroids as dengue therapeutics: resolving clinical observations with a primary human macrophage model

Andrew C Sayce, Joanna L Miller, Nicole Zitzmann
Comment

Glucocorticosteroids as dengue therapeutics: resolving clinical observations with a primary human macrophage model

Andrew C Sayce et al. Clin Infect Dis. 2013 Mar.
No abstract available

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Figures

Figure 1.
Figure 1.
A, Dengue virus titer kinetics in primary monocyte-derived macrophages from 5 donors in the absence (black bars) or presence (gray bars) of dexamethasone as determined by LLC-MK2 plaque assay. B–K, Equivalent kinetic assessment of cytokines and chemokines was conducted by performing custom Bio-Plex multiplex analysis with a Luminex 200 analyzer. Error bars represent standard errors, with significance (*α < .05, **α < .01) assessed by Mann-Whitney U nonparametric tests, owing to failure of Levene's test for homogeneity. All x-axis values represent days after infection (days 1, 3, and 5). Abbreviations: G-CSF, granulocyte colony-stimulating factor; IFN-γ, interferon γ; IL-6, interleukin 6; IL-8, interleukin 8; IL-10, interleukin 10; IL-17A, interleukin 17A; MCP-1, monocyte chemoattractant protein 1; MIF, macrophage migration inhibitory factor; PFUs, plaque-forming units; TNF- α, tumor necrosis factor α.
See this image and copyright information in PMC

Comment in

  • Reply to Halstead and Sayce et al.
    Tam DT, Simmons CP, Wills BA. Tam DT, et al. Clin Infect Dis. 2013 Mar;56(6):903-4. doi: 10.1093/cid/cis1049. Epub 2012 Dec 14. Clin Infect Dis. 2013. PMID: 23243184 Free PMC article. No abstract available.

Comment on

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