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. 2012 Oct;29(4):354-62.
doi: 10.4103/0970-2113.102824.

Digital clubbing

Malay Sarkar  1 , D M Mahesh, Irappa Madabhavi
Affiliations

Digital clubbing

Malay Sarkar et al. Lung India. 2012 Oct.

Abstract

Digital clubbing is an ancient and important clinical signs in medicine. Although clubbed fingers are mostly asymptomatic, it often predicts the presence of some dreaded underlying diseases. Its exact pathogenesis is not known, but platelet-derived growth factor and vascular endothelial growth factor are recently incriminated in its causation. The association of digital clubbing with various disease processes and its clinical implications are discussed in this review.

Keywords: Cancer; digital clubbing; hypertrophic osteoarthropathy; megakaryocytes; vascular endothelial growth factor.

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Conflict of interest statement

Conflict of Interest: None declared

Figures

Figure 1
Figure 1
(a-b) Depicting profile and hyponychial angle in normal and clubbed fingers. DBC and DBA are the normal profile and hyponychial angle and ABD and ABC are the increased profile and hyponychial angle in clubbed fingers
Figure 2
Figure 2
Showing phalangeal depth ratio In normal finger (a), interphalangeal depth (IPD) is more than distal phalangeal depth (DPD) which is altered in clubbed digits (b)
Figure 3
Figure 3
Showing normal diamond shaped space
Figure 4
Figure 4
Showing the pathogenesis of digital clubbing
See this image and copyright information in PMC

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