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. 2012 Oct;29(4):366-9.
doi: 10.4103/0970-2113.102831.

Kartagener's syndrome: A case series

Mayank Mishra  1 , Naresh Kumar, Ashish Jaiswal, Ajay K Verma, Surya Kant
Affiliations

Kartagener's syndrome: A case series

Mayank Mishra et al. Lung India. 2012 Oct.

Abstract

Kartagener's syndrome is a rare, autosomal recessive genetic ciliary disorder comprising the triad of situs inversus, chronic sinusitis, and bronchiectasis. The basic problem lies in the defective movement of cilia, leading to recurrent chest infections, ear/nose/throat symptoms, and infertility. We hereby report three unusual cases of this rare entity - an infertile male with azoospermia in whom Bochdalek's diaphragmatic hernia coexisted, another case of an infertile female, and a third of an infertile male with oligospermia. The need for a high index of suspicion to make an early diagnosis cannot be overemphasized in such patients so that wherever possible, options for timely treatment of infertility may be offered and unnecessary evaluation of symptoms is avoided.

Keywords: Bronchiectasis; Kartagener's syndrome; sinusitis; situs inversus.

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Conflict of interest statement

Conflict of Interest: None declared

Figures

Figure 1
Figure 1
(a) Chest X-ray PA view showing dextrocardia and left-sided Bochdalek's hernia; (b) CECT-chest showing right-sided bronchiectasis, dextrocardia, and left-sided Bochdalek's herina
Figure 2
Figure 2
(a) X-ray PNS showing opacified maxillary sinuses; (b) chest X-ray PA view showing dextrocardia and left-sided bronchiectasis
Figure 3
Figure 3
(a) Cystic bronchiectactic changes in the lower and mid zones with dextrocardia; (b) axial CT image abdomen showing situs inversus with the liver and IVC on the left and the spleen and aorta on the right; (c) axial CT image paranasal sinuses showing mucosal thickening and opacified sinus cavities
See this image and copyright information in PMC

References

    1. Barthwal MS. Kartagener's syndrome in a fertile male - An uncommon variant. Lung India. 2006;23:123–5.
    1. Dixit R, Dixit K, Jindal S, Shah KV. An unusual presentation of immotile-cilia syndrome with azoospermia: Case report and literature review. Lung India. 2009;26:142–5. - PMC - PubMed
    1. Seaton D. Bronchiectasis. In: Seaton A, Seaton D, Leitch AG, editors. Crofton and Douglas's respiratory diseases. 5th ed. Oxford: Blackwell Science; 2004. pp. 794–828.
    1. Barbato A, Frischer T, Kuehni CE, Snijders D, Azevedo I, Baktai G, et al. Primary ciliary dyskinesia: A consensus statement on diagnostic and treatment approaches in children. Eur Respir J. 2009;34:1264–76. - PubMed
    1. Marthin JK, Petersen N, Skovgaard LT, Nielsen KG. Lung function in patients with primary ciliary dyskinesia: A cross-sectional and 3-decade longitudinal study. Am J Respir Crit Care Med. 2010;181:1262–8. - PubMed