Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Nov 1;1(8):1409-1410.
doi: 10.4161/onci.21059.

NY-ESO-1 expression in sarcomas: A diagnostic marker and immunotherapy target

Jin-Ping Lai  1 , Avi Z Rosenberg, Markku M Miettinen, Chyi-Chia R Lee
Affiliations

NY-ESO-1 expression in sarcomas: A diagnostic marker and immunotherapy target

Jin-Ping Lai et al. Oncoimmunology. .

Abstract

NY-ESO-1 (CTAG 1B) is highly expressed in the majority of synovial sarcomas and myxoid/round cell liposarcomas as well as in a subset of melanomas, but only rarely in other mesenchymal tumors. This points to a potential for using NY-ESO-1 in the differential diagnosis of these lesions. Furthermore, promising results have been obtained in clinical trials testing NY-ESO-1-targeted immunotherapy in subsets of melanoma and synovial sarcoma patients.

PubMed Disclaimer

Figures

None
Figure 1. Immunohistochemical detection of NY-ESO-1 in human sarcomas and in metastatic malignant melanoma. (A) synovial sarcoma (400x). (B) metastatic malignant melanoma (400x). (C) myxoid/round cell liposarcoma (400x). (D) metastatic gastrointestinal stromal tumor with epithelial and spindle cell features (400x).
See this image and copyright information in PMC

References

    1. Mashino K, Sadanaga N, Tanaka F, Yamaguchi H, Nagashima H, Inoue H, et al. Expression of multiple cancer-testis antigen genes in gastrointestinal and breast carcinomas. Br J Cancer. 2001;85:713–20. doi: 10.1054/bjoc.2001.1974. - DOI - PMC - PubMed
    1. Robbins PF, Morgan RA, Feldman SA, Yang JC, Sherry RM, Dudley ME, et al. Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1. J Clin Oncol. 2011;29:917–24. doi: 10.1200/JCO.2010.32.2537. - DOI - PMC - PubMed
    1. Jungbluth AA, Antonescu CR, Busam KJ, Iversen K, Kolb D, Coplan K, et al. Monophasic and biphasic synovial sarcomas abundantly express cancer/testis antigen NY-ESO-1 but not MAGE-A1 or CT7. Int J Cancer. 2001;94:252–6. doi: 10.1002/ijc.1451. - DOI - PubMed
    1. Lai JP, Robbins PF, Raffeld M, Aung PP, Tsokos M, Rosenberg SA, et al. NY-ESO-1 expression in synovial sarcoma and other mesenchymal tumors: significance for NY-ESO-1-based targeted therapy and differential diagnosis. Mod Pathol. 2012;25:854–8. doi: 10.1038/modpathol.2012.31. - DOI - PMC - PubMed
    1. Chen YT, Scanlan MJ, Sahin U, Türeci O, Gure AO, Tsang S, et al. A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening. Proc Natl Acad Sci U S A. 1997;94:1914–8. doi: 10.1073/pnas.94.5.1914. - DOI - PMC - PubMed

LinkOut - more resources