Recollection and familiarity in schizophrenia: a quantitative review
- PMID: 23245761
- PMCID: PMC3609900
- DOI: 10.1016/j.biopsych.2012.10.027
Recollection and familiarity in schizophrenia: a quantitative review
Abstract
Recognition memory judgments can be based on recollection of qualitative information about an earlier study event or on assessments of stimulus familiarity. Schizophrenia is associated with pronounced deficits in overall recognition memory, and these deficits are highly predictive of global functioning. However, the extent to which these deficits reflect impairments in recollection or familiarity is less well understood. In the current article, we reviewed studies that used remember-know-new, process dissociation, and receiver operating characteristic procedures to investigate recollection and familiarity in schizophrenia. We also performed a quantitative reanalysis of these study results to obtain recollection and familiarity estimates that account for methodological differences between studies. Contrary to previous conclusions that recollection is selectively impaired in schizophrenia, we found evidence for both familiarity and recollection deficits across studies, suggesting multi-focal medial temporal lobe and/or prefrontal cortex dysfunction. The familiarity deficits were more variable with frequent small-to-medium rather than medium-to-large effect sizes, suggesting that familiarity could be potentially used as a compensatory ability, whereas recollection is conceptualized as a therapeutic target for new treatment development.
Copyright © 2013 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
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References
-
- Aleman A, Hijman R, de Haan EH, Kahn RS. Memory impairment in schizophrenia: a meta-analysis. Am J Psychiatry. 1999;156:1358–1366. - PubMed
-
- Gold JM, Randolph C, Carpenter CJ, Goldberg TE, Weinberger DR. Forms of memory failure in schizophrenia. J Abnorm Psychol. 1992;101:487–494. - PubMed
-
- Clare L, McKenna PJ, Mortimer AM, Baddeley AD. Memory in schizophrenia: what is impaired and what is preserved? Neuropsychologia. 1993;31:1225–1241. - PubMed
-
- Green MF. What are the functional consequences of neurocognitive deficits in schizophrenia? Am J Psychiatry. 1996;153:321–330. - PubMed
-
- Milev P, Ho BC, Arndt S, Andreasen NC. Predictive values of neurocognition and negative symptoms on functional outcome in schizophrenia: a longitudinal first-episode study with 7-year follow-up. Am J Psychiatry. 2005;162:495–506. - PubMed
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