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Randomized Controlled Trial
. 2012 Nov-Dec;44(6):784-7.
doi: 10.4103/0253-7613.103302.

Comparison of safety and efficacy of papaya dressing with hydrogen peroxide solution on wound bed preparation in patients with wound gape

Mangala B Murthy  1 , Bhasker K Murthy, Sanjay Bhave
Affiliations
Randomized Controlled Trial

Comparison of safety and efficacy of papaya dressing with hydrogen peroxide solution on wound bed preparation in patients with wound gape

Mangala B Murthy et al. Indian J Pharmacol. 2012 Nov-Dec.

Abstract

Objective: Indian papaya or Carica papaya is known to have de-sloughing and wound-healing properties due to the presence of protease enzymes. The present study was done to compare the efficacy and safety of papaya dressing with hydrogen peroxide solution for preparation of wound bed in patients of postoperative wound gape.

Materials and methods: A randomized, open-labeled interventional study was carried out over a period of 8 months at a tertiary care hospital on post-caesarean section patients with wound gape. The efficacy parameters studied were duration of time required to induce development of healthy granulation tissue and total duration of hospitalization. Safety parameters studied were adverse effects reported by patients and development of hypersensitivity reaction.

Results: A total of 64 patients were enrolled, of which 32 patients received hydrogen peroxide dressing and 31 patients received papaya dressing (one patient withdrew after randomization). Time required to induce the development of healthy granulation tissue and total duration of hospitalization were 6.2±1.6 days vs 2.5±0.5 days and 19.2±5.8 days vs 12.92±4.6 days in papaya and hydrogen peroxide dressing groups, respectively. Both primary efficacy parameters were significantly shorter in papaya dressing group. The incidence of adverse effects like local irritation and itching were comparable in both groups and the difference was not statistically significant.

Conclusion: Papaya dressing is more efficacious and equally safe as compared to hydrogen peroxide dressing when used for wound bed preparation in patients with postoperative wound gape.

Keywords: Hydrogen peroxide; papaya; wound debridement; wound gape.

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Conflict of interest statement

Conflict of Interest: No.

Figures

Figure 1
Figure 1
CONSORT 2010 Flow Diagram
Figure 2
Figure 2
Comparison of time required to achieve specified end point and total duration of hospitalization in group A and group B
Figure 3
Figure 3
Comparison of group A and group B with respect to the number of patients requiring partial surgical wound debridement and repeat re-suturing
Figure 4
Figure 4
Comparison of safety profile of the two groups
See this image and copyright information in PMC

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