Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Nov-Dec;44(6):788-91.
doi: 10.4103/0253-7613.103303.

Evaluation of anti-inflammatory activity of Typha angustifolia pollen grains extracts in experimental animals

Saroj S Varpe  1 , Archana R Juvekar, Mukta P Bidikar, Parikshit R Juvekar
Affiliations

Evaluation of anti-inflammatory activity of Typha angustifolia pollen grains extracts in experimental animals

Saroj S Varpe et al. Indian J Pharmacol. 2012 Nov-Dec.

Abstract

Objective: This study was designed to evaluate the anti-inflammatory activity of aqueous and 70% methanolic extracts of pollen grains of Typha angustifolia.

Materials and methods: Female Sprague Dawley rats were used for the study. The acute anti-inflammatory activity of pollen grains of T. angustifolia was studied using the carrageenan as phlogistic agent, whereas its chronic anti-inflammatory effect was investigated by the percentage inhibition of cotton pellet-induced granuloma.

Results: Both aqueous and 70% methanolic extracts of pollen grains of T. angustifolia showed significant dose-dependent inhibition of carrageenan-induced paw edema as compared to the control (P<0.001). It was observed that both the extracts at dose of 125 mg/kg inhibited the granuloma formation by 44.30% which is higher than at dose of 500, 250 mg/kg, thus causing a significant (P<0.001) non-dose-related inhibition of granuloma formation.

Conclusion: The results of this study indicate that extracts of pollen grains of T. angustifolia are effective in the treatment of both acute and chronic inflammatory conditions and thus support its traditional utilization.

Keywords: Anti-inflammatory; Typha angustifolia; carrageenan; cotton pellet-induced granuloma.

PubMed Disclaimer

Conflict of interest statement

Conflicting Interest: No.

References

    1. Kumar V, Abbas AK, Fausto N. Robbins and Cotran Pathologic Basis of Disease. 7th ed. Philadelphia: Elsevier Publication; 1999. pp. 48–87.
    1. Kirtikar KR, Basu BD. Indian Medicinal Plants. 2nd ed. Vol. 4. Allahabad: Published by Lalit Mohan Basu; 1975. pp. 2595–6.
    1. Gupta A, Mishra AK, Bansal P, Kumar S, Sannd R, Gupta V, et al. Antileprotic Potential of Ethnomedicinal Herbs: A Review. Drug Invent Today. 2010;2:191–3.
    1. Tao W, Yang N, Duan JA, Wu D, Guo J, Tang Y, et al. Simultaneous determination of eleven major flavonoids in the pollen of Typha angustifolia by HPLC-PDA-MS. Phytochem Anal. 2011;22:455–61. - PubMed
    1. Qin F, Sun HX. Immunosuppressive activity of Pollen Typhae ethanol extract on the immune responses in mice. J Ethnopharmacol. 2005;102:424–9. - PubMed

Publication types