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Case Reports
. 2012 Jul;33(3):176-8.
doi: 10.4103/0971-5851.103148.

Uterine smooth muscle tumor of uncertain malignant potential: A rare cause of multiple pulmonary nodules

Ioannis C Kotsopoulos  1 , Nikolaos Barbetakis, Christos Asteriou, Markos G Voutsas
Affiliations
Case Reports

Uterine smooth muscle tumor of uncertain malignant potential: A rare cause of multiple pulmonary nodules

Ioannis C Kotsopoulos et al. Indian J Med Paediatr Oncol. 2012 Jul.

Abstract

Smooth muscle tumors of uncertain malignant potential (STUMP) are mesenchymal uterine tumors lying between benign leiomyomas and leiomyosarcomas. Although lung metastases from uterine leiomyosarcoma are common, "STUMP" usually does not metastasize. A case of a 51-year-old woman with progressive dyspnea on exertion and multiple space-occupying lesions in both lungs is presented. She had a history of a total abdominal hysterectomy 3 years ago. Lung biopsy through video-assisted thoracic surgery was consistent with metastatic malignant smooth muscle cell tumor. She received multiple cycles of chemotherapy and died 11 months later. Cell necrosis, atypia and mitotic count are important criteria determining the malignant potential of a uterine smooth muscle tumor. The diagnosis and clinical course of STUMP are not totally and clearly known, and metastasis, especially pulmonary with pleural effusion, is not a common phenomenon. When this occurs, prognosis seems to be poor. Surveillance of these patients should be close and long term.

Keywords: Leiomyoma; leiomyosarcoma; lung; metastasis; uterus.

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Conflict of interest statement

Conflict of Interest: None declared

Figures

Figure 1
Figure 1
Uterine smooth muscle tumor with mild mitotic activity (smooth muscle tumors of uncertain malignant potential tumor)
Figure 2
Figure 2
Chest computed tomography was consistent with multiple pulmonary nodules and pleural effusion
Figure 3
Figure 3
Pathology was consistent with a metastatic pulmonary leiomyosarcoma
See this image and copyright information in PMC

References

    1. Ip PP, Cheung AN, Clement PB. Uterine smooth muscle tumors of uncertain malignant potential (STUMP): a clinicopathologic analysis of 16 cases. Am J Surg Pathol. 2009;33:992–1005. - PubMed
    1. Unver NU, Acikalin MF, Oner U, Ciftci E, Ozalp SS, Colak E. Differential expression of P16 and P21 in benign and malignant uterine smooth muscle tumors. Arch Gynecol Obstet. 2011;284:483–90. - PubMed
    1. Ng JS, Han A, Chew SH, Low J. A clinicopathologic study of uterine smooth muscle tumours of uncertain malignant potential (STUMP) Ann Acad Med Singapore. 2010;39:625–8. - PubMed
    1. Kong CS, Longacre TA, Hendrickson MR. Pathology. In: Berek JS, Hacker NF, editors. Gynecologic Oncology. 5th ed. Philadelphia: Lippincott Williams and Wilkins; 2010. pp. 166–70. Section I, chapter 5.
    1. Hacker NF, Friedlander M. Uterine Cancer. In: Berek JS, Hacker NF, editors. Gynecologic Oncology. 5th ed. Philadelphia: Lippincott Williams and Wilkins; 2010. pp. 430–2.

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