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Comparative Study
. 2012 Oct;19(4):361-3.
doi: 10.4103/0974-9233.102740.

Isolates and antibiotic resistance of culture-proven endophthalmitis cases presented to a referral center in Tehran

Khalil Ghasemi Falavarjani  1 , Shahbaz Nekoozadeh, Mehdi Modarres, Mohammad M Parvaresh, Masih Hashemi, Reza Soodi, Sayyed Amirpooya Alemzadeh
Affiliations
Comparative Study

Isolates and antibiotic resistance of culture-proven endophthalmitis cases presented to a referral center in Tehran

Khalil Ghasemi Falavarjani et al. Middle East Afr J Ophthalmol. 2012 Oct.

Abstract

Purpose: To evaluate the spectrum of organisms causing endophthalmitis and their resistance pattern to standard antimicrobial agents.

Materials and methods: Medical records of culture positive eyes treated at Rassoul Akram Hospital for endophthalmitis during the past 5 years were reviewed. Specimens were obtained during pars plana vitrectomy or vitreous tap.

Results: Sixty-five isolates including 36 (55.4%) gram-positive organisms, 28 gram-negative organisms (43.1%), and 1 (1.5%) fungus were studied. The most common organism identified was Coagulase-negative staphylococcus in 16 eyes (24.6%). Among the antibiotics available for intravitreal injection, the least antibiotic resistance was for vancomycin in gram-positive organisms and amikacin and ceftazidime in gram-negative isolates.

Conclusions: Gram-positive isolates were the most prevalent organisms; however, a high isolation rate for gram-negative organisms was obtained. Considering that no single antibiotic provides coverage for all of the organisms, a combination therapy using vancomycin/amikacin or vancomycin/ceftazidime seems to be useful as the initial empiric treatment of suspected bacterial endophthalmitis.

Keywords: Antibiotic; Culture; Endophthalmitis; Microorganism.

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Conflict of interest statement

Conflict of Interest: None declared.

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