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. 2012 Oct;4(4):258-66.
doi: 10.4103/0975-7406.103231.

Formulation and delivery of vaccines: Ongoing challenges for animal management

Sameer Sharma  1 , Lyn A Hinds
Affiliations

Formulation and delivery of vaccines: Ongoing challenges for animal management

Sameer Sharma et al. J Pharm Bioallied Sci. 2012 Oct.

Abstract

Development of a commercially successful animal vaccine is not only influenced by various immunological factors, such as type of antigen but also by formulation and delivery aspects. The latter includes the need for a vector or specific delivery system, the choice of route of administration and the nature of the target animal population and their habitat. This review describes the formulation and delivery aspects of various types of antigens such as killed microorganisms, proteins and nucleic acids for the development of efficacious and safe animal vaccines. It also focuses on the challenges associated with the different approaches that might be required for formulating and delivering species specific vaccines, particularly if their intended use is for improved animal management with respect to disease and/or reproductive control.

Keywords: Delivery systems; domestic animals; formulation; immunocontraception; immunological adjuvants; vaccines; wildlife.

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Conflict of interest statement

Conflict of Interest: None declared

Figures

Figure 1
Figure 1
Schematic representation of reproductive targets used for the development of immunocontraceptive vaccines
See this image and copyright information in PMC

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