Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012:4:181-4.
doi: 10.2147/HIV.S24432. Epub 2012 Dec 5.

Clinical utility and consumer considerations for the use of once-daily nevirapine extended release for HIV infection treatment

Eric W Pefura Yone  1 , André P Kengne
Affiliations

Clinical utility and consumer considerations for the use of once-daily nevirapine extended release for HIV infection treatment

Eric W Pefura Yone et al. HIV AIDS (Auckl). 2012.

Abstract

An extended-release formulation of nevirapine (NVP-XR) has been developed with the aim of simplifying antiretroviral treatment regimens and improving patients' adherence with a single daily intake. The VERxVE and TRANxITION clinical trials have demonstrated the noninferiority of NVP-XR compared with nevirapine immediate-release (NVP-IR) on viral load after 24 and 48 months of treatment. The tolerance profiles of NVP-XR and NVP-IR are similar. Simplifying the treatment dosage for NVP would likely improve adherence to antiretroviral treatments.

Keywords: HIV infection; antiretroviral therapy; efficacy; nevirapine extended release; safety.

PubMed Disclaimer

References

    1. Egger M, May M, Chene G, et al. Prognosis of HIV-1-infected patients starting highly active antiretroviral therapy: a collaborative analysis of prospective studies. Lancet. 2002;360:119–129. - PubMed
    1. Palella FJ, Jr, Delaney KM, Moorman AC, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med. 1998;338:853–860. - PubMed
    1. Organisation Mondiale de la Santé. Recommandations rapides: Traitement antirétroviral de l’infection à VIH chez l’adulte et l’adolescent. 2010. [Accessed December 12, 2011]. Available from: http://www.who.int/hiv/pub/arv/rapid_advice_art_fr.pdf.
    1. Thompson MA, Aberg JA, Cahn P, et al. Antiretroviral treatment of adult HIV infection: 2010 recommendations of the International AIDS Society-USA panel. JAMA. 2010;304:321–333. - PubMed
    1. Thompson MA, Aberg JA, Hoy JF, et al. Antiretroviral treatment of adult HIV infection: 2012 recommendations of the International Antiviral Society-USA panel. JAMA. 2012;308:387–402. - PubMed

LinkOut - more resources