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. 2012 Dec 18;4(1):53.
doi: 10.1186/1758-5996-4-53.

Undercarboxylated osteocalcin does not correlate with insulin resistance as assessed by euglycemic hyperinsulinemic clamp technique in patients with type 2 diabetes mellitus

Katsuhito Mori  1 , Masanori Emoto, Koka Motoyama, Eiko Lee, Shinsuke Yamada, Tomoaki Morioka, Yasuo Imanishi, Tetsuo Shoji, Masaaki Inaba
Affiliations

Undercarboxylated osteocalcin does not correlate with insulin resistance as assessed by euglycemic hyperinsulinemic clamp technique in patients with type 2 diabetes mellitus

Katsuhito Mori et al. Diabetol Metab Syndr. .

Abstract

Background: Recent in vitro and in vivo studies have suggested a critical role of osteocalcin (OC), especially the undercarboxylated form (ucOC), in insulin secretion and insulin sensitivity. The objective of this study was to investigate the association between serum ucOC levels and insulin resistance in humans with type 2 diabetes mellitus.

Findings: We measured serum ucOC levels in 129 patients with type 2 diabetes. Insulin resistance was assessed using the euglycemic hyperinsulinemic clamp technique. The insulin resistance indices used were the M value, which is the total body glucose disposal rate, and the M/I value, which is the M value adjusted for the steady state plasma insulin level. ucOC levels were not correlated with the M value (ρ = -0.013, p = 0.886) or the M/I value (ρ = 0.001, p = 0.995).

Conclusions: We found no association between ucOC levels and insulin resistance in patients with type 2 diabetes mellitus.

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Figures

Figure 1
Figure 1
The association between serum ucOC levels and M (A) and M/I values (B). There was no significant association of serum ucOC levels and M (ρ = −0.013, p = 0.886) and M/I values (ρ = 0.001, p = 0.995).
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References

    1. Motyl KJ, McCabe LR, Schwartz AV. Bone and glucose metabolism: a two-way street. Arch Biochem Biophys. 2010;503:2–10. doi: 10.1016/j.abb.2010.07.030. - DOI - PMC - PubMed
    1. Ng KW. Regulation of glucose metabolism and the skeleton. Clin Endocrinol. 2011;75:147–155. doi: 10.1111/j.1365-2265.2011.04133.x. - DOI - PubMed
    1. Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, Dacquin R, Mee PJ, McKee MD, Jung DY, Zhang Z, Kim JK, Mauvais-Jarvis F, Ducy P, Karsenty G. Endocrine regulation of energy metabolism by the skeleton. Cell. 2007;130:456–469. doi: 10.1016/j.cell.2007.05.047. - DOI - PMC - PubMed
    1. Ferron M, Hinoi E, Karsenty G, Ducy P. Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc Natl Acad Sci. 2008;105:5266–5270. doi: 10.1073/pnas.0711119105. - DOI - PMC - PubMed
    1. Ferron M, McKee MD, Levine RL, Ducy P, Karsenty G. Intermittent injections of osteocalcin improve glucose metabolism and prevent type 2 diabetes in mice. Bone. 2012;50:568–575. doi: 10.1016/j.bone.2011.04.017. - DOI - PMC - PubMed

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