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. 2012 Dec 18:10:273.
doi: 10.1186/1477-7819-10-273.

Analysis of the tumor length and other prognosis factors in pT1-2 node-negative esophageal squamous cell carcinoma in a Chinese population

Zhengbo Song  1 , Jiwen Wang, Baochai Lin, Yiping Zhang
Affiliations

Analysis of the tumor length and other prognosis factors in pT1-2 node-negative esophageal squamous cell carcinoma in a Chinese population

Zhengbo Song et al. World J Surg Oncol. .

Abstract

Background: Tumor length is an important prognostic factor for many carcinomas, but its role in esophageal cancer remained undetermined. The aim of this study was to investigate the effect of tumor length on survival for patients with confined tumors (grade pT1-2) without lymph-node metastases in esophageal squamous cell carcinoma.

Methods: We enrolled 201 patients with esophageal squamous cell carcinoma (SCC) who had undergone surgical resection and been confirmed as pT1-2N0M0. The relationship of tumor length with overall survival was assessed and compared with other factors detailed in the American Joint Committee on Cancer (AJCC) tumor, node, metastasis (TNM) staging system published in 2009.

Results: The overall survival (OS) rates at 1, 3, and 5 years were 93.0%, 83.7%, and 69.2%, respectively. The tumor length adversely affected OS, with the 5-year rate being 93.5%, 82.0%, 68.6%, 67.9%, 55.3% and 41.1%, respectively for tumor lengths of less than 10 mm, 10 to 20 mm, 20 to 30 mm, 30 to 40 mm, 40 to 50 mm, and greater than 50 mm (P< 0.001). Multivariate analyses showed that the pathologic T classification and grade of tumor was significantly associated with OS. Tumor length of 30 mm or more remained an independent prognostic factor (P = 0.04), as did the other current TNM factors.

Conclusion: Tumor length appears to affect the OS of patients with early-stage esophageal squamous cell carcinoma. It may provide additional prognostic information for the current TNM staging system.

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Figures

Figure 1
Figure 1
Kaplan–Meier survival curves in 201 patients with R0-resected esophageal carcinoma, comparing tumor length of 30 mm or less and greater than 30 mm (P = 0.01).
Figure 2
Figure 2
Kaplan–Meier survival curves in 201 patients with R0-resected early-stage esophageal carcinoma comparing tumor length in 10 mm increments (P<0.001).
Figure 3
Figure 3
Kaplan–Meier survival curves in 91 patients assessed as pT1, comparing tumor length of 30 mm or less and greater than 30 mm (P = 0.04).
Figure 4
Figure 4
Kaplan–Meier survival curves in 110 patients assessed as pT2, comparing tumor length of 30 mm or less and greater than 30 mm (P = 0.017).
See this image and copyright information in PMC

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