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. 2012 Jan;3(1):38-41.
doi: 10.4103/0975-5950.102150.

Effect of plasma rich in growth factors on alveolar osteitis

Afshin Haraji  1 , Eshagh Lassemi, Mohammad Hosein Kalantar Motamedi, Maryam Alavi, Saman Adibnejad
Affiliations

Effect of plasma rich in growth factors on alveolar osteitis

Afshin Haraji et al. Natl J Maxillofac Surg. 2012 Jan.

Abstract

Introduction: The high prevalence of dry socket or alveolar osteitis (AO) is of concern in surgical removal of third molars. The aim of the present study was to assess the preventive effect of plasma rich in growth factors (PRGF) on AO and also its effect on pain management and healing acceleration in third molar extraction sockets of high-risk patients.

Materials and methods: This split-mouth, double-blind clinical trial included 40 bilateral third molar extractions (80 sockets) with at least one identified risk factor for AO. PRGF was obtained from patient's own blood, based on manufacturer's instruction, and blindly placed in one of the two bilateral sockets (PRGF group; n = 20) of each patient. The contralateral socket was treated with a placebo (control group; n = 20). Samples were evaluated for AO and pain incidence on days 2, 3 and 4 and healing and infection on days 3 and 7. Data were analyzed in SPSS v16 using Wilcoxon test.

Results: There was a significant difference in dry socket and pain incidence and healing rate between the two groups. Intensity of pain and occurrence of dry socket in the study group was lower than the controls. Also the healing rate was higher (P < 0.05) for the PRGF group. No sign of infection was seen in either group.

Conclusion: The application of PRGF may significantly reduce the incidence of AO or its associated pain and may accelerate healing. The prophylactic use of PRGF following third molar extraction may be suggested especially in the patients at risk of AO.

Keywords: Dry socket; PRP; plasma rich in growth factors; third molar extraction.

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Conflict of interest statement

Conflict of Interest: None declared

Figures

Figure 1
Figure 1
The comparative illustration of the pain intensity (mean ± standard deviation) felt by the patients (scored on VAS) on the second, the third and the fourth days following the third molar extraction. P2: PRGF group in the second day. C4: control group in the fourth day. Gray triangles represent PRGF group and the white ones represent control group
Figure 2
Figure 2
The comparative illustration of the healing scores (mean ± standard deviation) on the third and the seventh days following the third molar extraction. P3: PRGF group in the second day. C7: control group in the fourth day. Gray triangles represent PRGF group and the white ones represent control group
See this image and copyright information in PMC

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