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. 2011 Nov;7(4):319-327.
doi: 10.2174/157339411797642597.

Leptomeningeal Metastasis: Challenges in Diagnosis and Treatment

Ticiana Leal  1 , Julie E Chang, Minesh Mehta, H Ian Robins
Affiliations

Leptomeningeal Metastasis: Challenges in Diagnosis and Treatment

Ticiana Leal et al. Curr Cancer Ther Rev. 2011 Nov.

Abstract

As therapeutic options and supportive care for the treatment of neoplastic disease have improved, there has been an associated increase in the incidence of leptomeningeal disease. In this review, the clinical presentation, natural history, diagnostic evaluation, and treatment options for this often devastating sequela of solid tumors, lymphoma, and leukemia will be summarized. The therapeutic efficacy of ionizing radiation, systemic agents, and intrathecal drugs will be examined from the existing literature. Additionally the pathophysiology, which in part defines the therapeutic limitations in approaching this patient population, will be discussed in order to assist in individualized clinical decision making.

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References

    1. Drappatz J, Batchelor T. Leptomeningeal metastasis. American society of clinical oncology educational book; 2009. pp. 100–105.
    1. Omar AI, Mason WP. Neurologic complications of cancer. 2nd edition. New York: Oxford University Press, Inc; 2009. Leptomeningeal metastases; pp. 240–281.
    1. Chamberlain MC. Neoplastic meningitis. J Clin Oncol. 2005;23:3605–3613. - PubMed
    1. Gleissner B, Chamberlain MC. Neoplastic meningitis. Lancet Neurol. 2006;5:443–452. - PubMed
    1. Groves M. Leptomeningeal metastases: Still a challenge ASCO educational book. 2008:80–87.