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. 2012 Dec;9(4):384-90.
doi: 10.4306/pi.2012.9.4.384. Epub 2012 Nov 12.

Effect of methylphenidate on sleep parameters in children with ADHD

Sang Heon Lee  1 , Wan Seok Seo, Hyung Mo Sung, Tae Young Choi, So Yeun Kim, So-Jeong Choi, Bon Hoon Koo, Jong Hun Lee
Affiliations

Effect of methylphenidate on sleep parameters in children with ADHD

Sang Heon Lee et al. Psychiatry Investig. 2012 Dec.

Abstract

Objective: The primary aim of this study was to investigate the acute impact of methylphenidate (MPH) on sleep parameters in attention-deficit/hyperactivity disorder (ADHD) children. The second aim was to investigate the different effects of intermediate- and longacting MPH on sleep parameters. The third aim was to test the different effects of dose and age on sleep parameters.

Methods: Ninety-three ADHD children were enrolled and randomized to two different MPH preparations. Baseline and daily sleep diaries were evaluated for four weeks after taking medication. Weekday and weekend bedtimes, wake-up times, sleep latencies and total sleep times were compared by weeks.

Results: After taking MPH, there was a significant delay in bedtimes and a significant reduction of total sleep time (TST) both on weekdays and at weekends. There was also a significant delay in wake-up time on weekdays. However, the difference was applied to younger age group children only. There was no difference in changes of TST between metadate-CD and OROS-MPH. There also was no difference in changes of TST with different doses of MPH.

Conclusion: MPH had negative impacts on sleep among young ADHD children, but different preparations and doses did not affect the result.

Keywords: ADHD; Children; Metadate-CD; Methylphenidate; OROS-MPH.

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Figures

Figure 1
Figure 1
Changing patterns of sleep parameters for four weekdays and weekends. *p<0.05 comparisons with baseline.
See this image and copyright information in PMC

References

    1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders: DSM-IV TR. Washington DC: American Psychiatric Association; 2000.
    1. Concannon PE, Tang YP. Management of attention deficit hyperactivity disorder: a parental perspective. J Paediatr Child Health. 2005;41:625–630. - PubMed
    1. Capp PK, Pearl PL, Conlon C. Methylphenidate HCl: therapy for attention deficit hyperactivity disorder. Expert Rev Neurother. 2005;5:325–331. - PubMed
    1. Dulcan M. Practice parameters for the assessment and treatment of children, adolescents, and adults with attention-deficit/hyperactivity disorder. American Academy of Child and Adolescent Psychiatry. J Am Acad Child Adolesc Psychiatry. 1997;36(10 Suppl):85S–121S. - PubMed
    1. Kratochvil CJ, Lake M, Pliszka SR, Walkup JT. Pharmacological management of treatment-induced insomnia in ADHD. J Am Acad Child Adolesc Psychiatry. 2005;44:499–501. - PubMed

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