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. 2012;7(12):e51372.
doi: 10.1371/journal.pone.0051372. Epub 2012 Dec 10.

Nationwide surveillance in uterine cancer: survival analysis and the importance of birth cohort: 30-year population-based registry in Taiwan

Chia-Yen Huang  1 , Chi-An Chen, Yu-Li Chen, Chun-Ju Chiang, Tsui-Hsia Hsu, Ming-Chieh Lin, Mei-Shu Lai, Chien-Jen Chen, San-Lin You, Wen-Fang Cheng
Affiliations

Nationwide surveillance in uterine cancer: survival analysis and the importance of birth cohort: 30-year population-based registry in Taiwan

Chia-Yen Huang et al. PLoS One. 2012.

Abstract

Introduction: Uterine cancer was the most rapidly increasing malignancy and the second most common gynecologic malignancy in Taiwan.

Methods: We analyzed the secular trend of uterine cancer incidence and compare the survival of women with uterine carcinomas and uterine sarcomas in Taiwan. Data on women diagnosed with uterine cancer between 1979 and 2008 were obtained from the Taiwan cancer registry. Survival data were analyzed by using Kaplan-Meier and Cox proportional hazards regression methods.

Results: Records of 11,558 women with uterine carcinomas and 1,226 women with uterine sarcomas were analyzed. The age-adjusted incidence rate of endometrioid adenocarcinoma increased from 0.83 per 100,000 women per year between 1979 and 1983 to 7.50 per 100,000 women per year between 2004 and 2008. The 5-year survival rate of women with endometrioid adenocarcinoma (83.2%) was higher than that for women with clear cell carcinoma (58.3%), serous carcinoma (54.4%), and carcinosarcoma (35.2%) (p<0.0001, log-rank test). The 5-year survival rates of women with low grade endometrial stromal sarcoma, endometrial stromal sarcoma, leiomyosarcoma (LMS), and adenosarcoma were 97.5%, 73.5%, 60.1%, and 77.2%, respectively (p<0.0001, log rank test). The histologic type of endometrioid adenocarcinoma, young age, and treatment period after 2000 were independent, favorable prognostic factors in women with uterine carcinomas by multivariate analysis. The histologic type of LMS, old age, and treatment period after 2000 were independent, poor prognostic factors in women with uterine sarcomas by multivariate analysis.

Conclusions: An increase over time in the number of patients with endometrioid adenocarcinomas was noted in this 30-year, nationwide, population-based study. Histologic type, age and treatment period were survival factors for uterine cancers. A more comprehensive assessment of uterine cancers and patient care should be undertaken on this increasingly common type of cancer.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Mean ages of patients with uterine cancers by different histologic subtypes in Taiwan, 1979–2008 (mean ±1.96 S.D.).
Figure 2
Figure 2. Secular trend of age-adjusted incidence rates of uterine cancer and female nasopharyngeal carcinoma, 1979–2008.
Figure 3
Figure 3. (A) Age-specific incidence rates of endometrioid adenocarcinomas by calendar year.
(B) Age-specific incidence rates of type II uterine carcinomas by calendar year. (C) Age-specific incidence rates of endometrioid adenocarcinomas by birth cohort.
Figure 4
Figure 4. Five-year observed survival rates of uterine carcinomas by different histologic types: 1990–2008.
Log-rank test X2 = 1105.72, p<0.0001.
Figure 5
Figure 5. Five-year observed survival rates of uterine sarcomas by different histologic types: 1990–2008.
Log-rank test X2 = 58.15, p<0.0001.
See this image and copyright information in PMC

References

    1. Siegel R, Naishadham D, Jemal A (2012) Cancer statistics, 2012. CA Cancer J Clin 62: 10–29. - PubMed
    1. TCRTF (2009) Taiwan Cancer Registry Task Forcec(TCRTF). Cancer Registry Annual Report. Taipei: Department of Health, The Executive Yuan; 2009.
    1. Ueda SM, Kapp DS, Cheung MK, Shin JY, Osann K, et al... (2008) Trends in demographic and clinical characteristics in women diagnosed with corpus cancer and their potential impact on the increasing number of deaths. Am J Obstet Gynecol 198: 218 e211–216. - PubMed
    1. Boll D, Verhoeven RH, van der Aa MA, Pauwels P, Karim-Kos HE, et al. (2012) Incidence and survival trends of uncommon corpus uteri malignancies in the Netherlands, 1989–2008. Int J Gynecol Cancer 22: 599–606. - PubMed
    1. Bokhman JV (1983) Two pathogenetic types of endometrial carcinoma. Gynecol Oncol 15: 10–17. - PubMed