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. 2010 Jul;1(4):163-75.
doi: 10.1177/2040622310380100.

Contemporary treatment of systemic lupus erythematosus: an update for clinicians

Maame B Amissah-Arthur  1 , Caroline Gordon
Affiliations

Contemporary treatment of systemic lupus erythematosus: an update for clinicians

Maame B Amissah-Arthur et al. Ther Adv Chronic Dis. 2010 Jul.

Abstract

The prognosis for patients with systemic lupus erythematosus (SLE) has improved significantly, with 20-year survival now approximately 80% owing partly to effective treatment. SLE treatment has evolved from the use of conventional drugs such as hydroxychloroquine and corticosteroids, nonspecific immunosuppressants including mycophenolate mofetil, to targeting selective components of the immune cascade with a view to increased efficacy, tolerability and safety profile. These novel treatments include B-cell-depleting antibodies and fusion proteins that block the costimulatory pathways of B and T cells. A discussion of these pharmacological options and ongoing research forms the basis of this review.

Keywords: B-cell therapy; SLE; autoimmune; immunosupressive; lupus; treatment.

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Conflict of interest statement

CG is or has been a paid consultant to, and received honoraria in the last 2 years from, Amgen, Aspreva/Vifor Pharma, Biogen, Bristol Myers Squibb, Genentech, GSK, Roche, Teva and UCB. CG has been in the speakers' bureau for BMS and UCB and has also received an unrestricted educational research grant from Aspreva/Vifor Pharma.

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