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Editorial
. 2013 Jan 1;12(1):9-10.
doi: 10.4161/cc.23324. Epub 2012 Dec 19.

p53 and DNA methylation suppress the TRAIN to cell death

Omid Tavana, Wei Gu
Editorial

p53 and DNA methylation suppress the TRAIN to cell death

Omid Tavana et al. Cell Cycle. .
No abstract available

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Figures

None
Figure 1. Schematic of TRAIN (transcription of repeats activates interferon)-induced cell death. In a hypomethylated state (caused from 5-aza-dc treatment), p53 suppresses the transcription of repetitive factors (SINE, GSAT, nc-RNA), which presumably form into double-stranded RNA to activate a “suicidal” interferon response leading to apoptosis specifically in a p53-deficient setting.
See this image and copyright information in PMC

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References

    1. Meek DW. Nat Rev Cancer. 2009;9:714–23. - PubMed
    1. Li T, et al. Cell. 2012;149:1269–83. doi: 10.1016/j.cell.2012.04.026. - DOI - PMC - PubMed
    1. Jackson JG, et al. Cancer Cell. 2012;21:793–806. doi: 10.1016/j.ccr.2012.04.027. - DOI - PMC - PubMed
    1. Nieto M, et al. Oncogene. 2004;23:735–43. doi: 10.1038/sj.onc.1207175. - DOI - PubMed
    1. Kantarjian HM, et al. Cancer. 2007;109:1133–7. doi: 10.1002/cncr.22508. - DOI - PMC - PubMed