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Review
. 2013 Jun;60(6):1027-30.
doi: 10.1002/pbc.24426. Epub 2012 Dec 19.

Children's Oncology Group's 2013 blueprint for research: cancer control and supportive care

Lillian Sung  1 , Theo Zaoutis, Nicole J Ullrich, Donna Johnston, Lee Dupuis, Elena Ladas; Children's Oncology Group Cancer Control and Supportive Care Committee
Affiliations
Review

Children's Oncology Group's 2013 blueprint for research: cancer control and supportive care

Lillian Sung et al. Pediatr Blood Cancer. 2013 Jun.

Abstract

In cancer control research, the objective is to reduce overall morbidity and mortality by decreasing acute and delayed treatment-related toxicities in all children with cancer. To date, the Children's Oncology Group (COG) has focused on infection, neurocognition, quality of life (QoL), and nutrition/antiemetics. COG is conducting randomized controlled trials (RCTs) to determine prophylaxis strategies that will reduce infections in high-risk populations. Two RCTs are determining if modafinil or computerized cognitive training improve cognitive functioning in pediatric brain tumor patients. QoL is being assessed in acute leukemia patients. Improved supportive care outcomes will only occur when the most effective interventions are established.

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References

    1. Alexander S, Nieder M, Zerr DM, et al. Prevention of bacterial infection in pediatric oncology: What do we know, what can we learn? Pediatr Blood Cancer. 2012;59:16–20. - PMC - PubMed
    1. Dvorak CC, Fisher BT, Sung L, et al. Antifungal prophylaxis in pediatric hematology/oncology: New choices & new data. Pediatr Blood Cancer. 2012;59:21–26. - PMC - PubMed
    1. Sung L, Gamis A, Alonzo TA, et al. Infections and association with different intensity of chemotherapy in children with acute myeloid leukemia. Cancer. 2009;115:1100–1108. - PMC - PubMed
    1. Sung L, Lange BJ, Gerbing RB, et al. Microbiologically documented infections and infection-related mortality in children with acute myeloid leukemia. Blood. 2007;110:3532–3539. - PubMed
    1. Sung L, Aplenc R, Alonzo TA, et al. Severe toxicities during pediatric acute myeloid leukemia chemotherapy: A report from the Children’s Oncology Group. Abstract presented at: American Society of Hematology Conference; December 2010; Orlando, Florida.

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