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Editorial
. 2013 Jun;60(6):955-6.
doi: 10.1002/pbc.24399. Epub 2012 Dec 19.

The Children's Oncology Group's 2013 five year blueprint for research

Peter C Adamson
Editorial

The Children's Oncology Group's 2013 five year blueprint for research

Peter C Adamson. Pediatr Blood Cancer. 2013 Jun.
No abstract available

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Figures

Fig. 1
Fig. 1
The COG plans to re-align its resources to better leverage research opportunities that will emerge during the next era of discovery. For many years, resources have been focused in quadrant IV: diseases for which the outcome is relatively good but the ability or availability of targeted new agents is limited to non-existent. Resources will need to shift towards the shaded region with a focus on quadrant II: diseases for which the outcome is moderate to poor but our ability to deliver a relevant targeted new agent is reasonably high. As we transition resources, there will still be a need to launch clinical investigations for diseases with very poor outcomes despite a limited knowledge of the molecular basis of disease (quadrant I); moreover, strong consideration will be given to diseases with reasonably good outcomes where a highly relevant targeted therapy is developed (quadrant III).
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