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. 2013 Jan;5(1):107-112.
doi: 10.3892/ol.2012.959. Epub 2012 Oct 9.

Annexin A1, A2, A4 and A5 play important roles in breast cancer, pancreatic cancer and laryngeal carcinoma, alone and/or synergistically

Shishan Deng  1 , Jianguo Wang, Lingmi Hou, Jinsui Li, Guo Chen, Baoqian Jing, Xiaoming Zhang, Zhengwei Yang
Affiliations

Annexin A1, A2, A4 and A5 play important roles in breast cancer, pancreatic cancer and laryngeal carcinoma, alone and/or synergistically

Shishan Deng et al. Oncol Lett. 2013 Jan.

Abstract

Annexins are associated with metastasis and infiltration of cancer cells. Proteomic analysis and immunohistochemical staining were used to understand whether several annexins play important roles in cancer alone and/or synergistically. Seven fresh breast cancer samples with 23 paraffin specimens, three fresh pancreatic samples and five fresh laryngeal carcinoma samples with 25 paraffin specimens were obtained from humans, as well as ten golden hamster pancreatic cancer tissue samples, and they were used to observe differential expression of annexins compared with normal tissues using proteomics and immunohistochemical staining. Annexin A2, A4 and A5 were overexpressed in human breast cancer and laryngeal carcinoma tissues and in golden hamster pancreatic cancer tissue samples, respectively, as shown by proteomics and immunohistochemical staining. In addition, annexin A4 and A5 were expressed in breast cancer tissues, while annexin A1 was not expressed. Annexin A1, A2 and A4 were expressed in human laryngeal carcinoma tissues as shown by immunohistochemical staining. Annexin A1, A2, A4 and A5 played important roles in breast cancer, pancreatic cancer and laryngeal carcinoma, alone and/or synergistically, and they may be targets of therapy for malignant tumors. The choice of which annexins to target should depend on their respective biological behaviors.

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Figures

Figure 1
Figure 1
Three differential protein spots from 2-DE gels were identified as annexin A2, A4 and A5 (→), respectively, by differential proteomics analysis, and the proteins were individually overexpressed in human breast cancer tissues (Bca), human laryngeal carcinoma tissues (Lca) and golden hamster pancreatic cancer tissues (Pca). 2-DE, two-dimensional polyacrylamide gel electrophoresis. Lno, normal laryngeal mucosal tissues; Pno, normal pancreatic tissues; Bno, normal breast tissues.
Figure 2
Figure 2
Three annexins that were further identified as positively expressed by immunohistochemical staining analysis were overexpressed in human breast cancer tissues (Bca), human laryngeal carcinom tissues (Lca) and golden hamster pancreatic cancer tissues (Pca), respectively.
Figure 3
Figure 3
By immunohistochemical staining analysis, annexin A4 (Ba4) and annexin A5 (Ba5) were shown to be positively expressed in breast cancer tissues but annexin A1 (Ba1) was negatively expressed. Annexin A1 (La1), annexin A2 (La2) and annexin A4 (La4) were expressed positively in human laryngeal carcinoma tissues.
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