Platelet-function testing in patients undergoing neurovascular procedures: caught between a rock and a hard place
- PMID: 23257609
- PMCID: PMC7964478
- DOI: 10.3174/ajnr.A3440
Platelet-function testing in patients undergoing neurovascular procedures: caught between a rock and a hard place
Abstract
In the context of neurointerventional procedures, clopidogrel hyper-responsiveness has been associated with hemorrhage; on the other hand, clopidogrel resistance has been associated with thromboembolism. This might seem to make a compelling argument in favor of routine platelet testing. Our reading of the literature leads us to conclude that routine platelet testing in neurointerventional procedures is not, unfortunately, ready for prime time.
Comment on
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Clopidogrel resistance is associated with thromboembolic complications in patients undergoing neurovascular stenting.AJNR Am J Neuroradiol. 2013 Apr;34(4):716-20. doi: 10.3174/ajnr.A3405. Epub 2012 Nov 29. AJNR Am J Neuroradiol. 2013. PMID: 23194833 Free PMC article.
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Clopidogrel hyper-response and bleeding risk in neurointerventional procedures.AJNR Am J Neuroradiol. 2013 Apr;34(4):721-6. doi: 10.3174/ajnr.A3418. Epub 2012 Dec 28. AJNR Am J Neuroradiol. 2013. PMID: 23275598 Free PMC article. Clinical Trial.
References
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- Combescure C, Fontana P, Mallouk N, et al. Clinical implications of clopidogrel non-response in cardiovascular patients: a systematic review and meta-analysis. J Thromb Haemost 2010;8:923–33 - PubMed
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- Breet N, van Werkum J, Bouman H, et al. Comparison of platelet function tests in predicting clinical outcome in patients undergoing coronary stent implantation. JAMA 2010;303:754–62 - PubMed
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- Gurbel P, Bliden K, Samara W, et al. Clopidogrel effect on platelet reactivity in patients with stent thrombosis: results of the CREST study. J Am Coll Cardiol 2005;46:1827–32 - PubMed
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