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Comment
. 2013 Jan;62(1):22-4.
doi: 10.2337/db12-1115.

Nlrp3 inflammasome activation in type 2 diabetes: is it clinically relevant?

Vishwa Deep Dixit  1
Affiliations
Comment

Nlrp3 inflammasome activation in type 2 diabetes: is it clinically relevant?

Vishwa Deep Dixit. Diabetes. 2013 Jan.
No abstract available

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Figures

FIG. 1.
FIG. 1.
Hypothetical model depicting the role of Nlrp3 inflammasome in type 2 diabetes. Metabolic stress–induced “danger signals” in type 2 diabetes such as islet amyloid polypeptide (IAPP), urate, extracellular ATP, fatty acids, endoplasmic reticulum (ER) stress, and reactive oxygen species (ROS) can be sensed by Nlrp3 inflammasome. The assembly of activated Nlrp3 inflammasome in myeloid cells by protein-protein interaction between Nlrp3, Asc, and (Cardinal) with procaspase-1 causes caspase-1 cleavage into P20 and P10 enzymatically active heterodimers that causes posttranslational processing of IL-1β and IL-18. Inflammation induced by inflammasome-dependent proinflammatory cytokines may produce insulin resistance or cause death of pancreatic β-cells leading to development of diabetes. AMPK, AMP-activated protein kinase; Sirt1, sirtuin 1.
See this image and copyright information in PMC

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References

    1. Hotamisligil GS, Erbay E. Nutrient sensing and inflammation in metabolic diseases. Nat Rev Immunol 2008;8:923–934 - PMC - PubMed
    1. Kanneganti TD, Dixit VD. Immunological complications of obesity. Nat Immunol 2012;13:707–712 - PubMed
    1. Donath MY, Shoelson SE. Type 2 diabetes as an inflammatory disease. Nat Rev Immunol 2011;11:98–107 - PubMed
    1. Talukdar S, Oh DY, Bandyopadhyay G, et al. Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase. Nat Med 2012;18:1407–1412 - PMC - PubMed
    1. Chawla A, Nguyen KD, Goh YP. Macrophage-mediated inflammation in metabolic disease. Nat Rev Immunol 2011;11:738–749 - PMC - PubMed

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