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Comment
. 2013 Jan;62(1):31-3.
doi: 10.2337/db12-1121.

A transcriptional blueprint for human and murine diabetic kidney disease

Vivek Bhalla  1 , Maria-Gabriela Velez, Glenn M Chertow
Affiliations
Comment

A transcriptional blueprint for human and murine diabetic kidney disease

Vivek Bhalla et al. Diabetes. 2013 Jan.
No abstract available

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Figures

FIG. 1.
FIG. 1.
The investigators used microarrays to analyze differential gene expression from glomeruli in four different comparisons and then generated signaling networks to represent each comparison. Nodes from each of these networks were then compared to examine the overlap between pathways that are altered in glomeruli from patients with clinical disease and three separate mouse models of diabetic nephropathy. In total, 26 shared nodes were present in all four models of the disease. BKS db/db, C57BLKS db/db mice; DBA STZ, streptozotocin-treated DBA/2 mice; eNOS, endothelial nitric oxide synthase.
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