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. 2012 Dec 19;103(12):L47-9.
doi: 10.1016/j.bpj.2012.11.009. Epub 2012 Dec 18.

Effects of familial mutations on the monomer structure of Aβ₄₂

Yu-Shan Lin, Vijay S Pande

Effects of familial mutations on the monomer structure of Aβ₄₂

Yu-Shan Lin et al. Biophys J. .

Abstract

Amyloid beta (Aβ) peptide plays an important role in Alzheimer's disease. A number of mutations in the Aβ sequence lead to familial Alzheimer's disease, congophilic amyloid angiopathy, or hereditary cerebral hemorrhage with amyloid. Using molecular dynamics simulations of ∼200 μs for each system, we characterize and contrast the consequences of four pathogenic mutations (Italian, Dutch, Arctic, and Iowa) for the structural ensemble of the Aβ monomer. The four familial mutations are found to have distinct consequences for the monomer structure.

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Figures

Figure 1
Figure 1
Ensemble-averaged %population of β-strand (top) and α-helix (bottom) propensity for all five monomer systems. The sequence of the WT Aβ42 is given on the x axis.
See this image and copyright information in PMC

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