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Comment
. 2012 Dec 21;151(7):1399-400.
doi: 10.1016/j.cell.2012.12.002.

Loaded dice for human genome mutation

Chris P Ponting  1
Affiliations
Free article
Comment

Loaded dice for human genome mutation

Chris P Ponting. Cell. .
Free article

Abstract

Not all bases in the human genome are equally prone to chance mutations. Michaelson et al. show that individuals can acquire clusters of de novo DNA changes and propose that the likelihood of single base pair change differs across three orders of magnitude.

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  • Whole-genome sequencing in autism identifies hot spots for de novo germline mutation.
    Michaelson JJ, Shi Y, Gujral M, Zheng H, Malhotra D, Jin X, Jian M, Liu G, Greer D, Bhandari A, Wu W, Corominas R, Peoples A, Koren A, Gore A, Kang S, Lin GN, Estabillo J, Gadomski T, Singh B, Zhang K, Akshoomoff N, Corsello C, McCarroll S, Iakoucheva LM, Li Y, Wang J, Sebat J. Michaelson JJ, et al. Cell. 2012 Dec 21;151(7):1431-42. doi: 10.1016/j.cell.2012.11.019. Cell. 2012. PMID: 23260136 Free PMC article.

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