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Comment
. 2012 Dec 21;151(7):1403-5.
doi: 10.1016/j.cell.2012.12.008.

A dimer to bridge early autophagosomal membranes

Fulvio Reggiori  1 , Christian Ungermann
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Free article
Comment

A dimer to bridge early autophagosomal membranes

Fulvio Reggiori et al. Cell. .
Free article

Abstract

The Atg1/ULK complex plays a key role in the early stages of autophagosome assembly. In this issue, Ragusa et al. reveal the molecular basis for some interactions within this complex, finding that the crescent-shaped Atg17 dimer is critical for autophagy, whereas Atg1 may have the ability to cluster membranes.

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