Visual field defects in patients with insulin-dependent and noninsulin-dependent diabetes

Abstract

Automated perimetry (Humphrey 30-2) was used to quantitate visual field sensitivity in diabetic patients with either little or no retinopathy (n = 38) or mild background diabetic retinopathy (n = 19) and in visually normal controls (n = 40). Foveal thresholds were unaffected in the diabetic patients but significant reductions in visual field sensitivity, measured by both the mean deviation and the pattern standard deviation indices of visual field sensitivity, were observed in the diabetic patients. Subgroup analyses showed that this sensitivity reduction primarily occurred in noninsulin-dependent diabetic patients. Among the diabetic patients, 26.3% of the visual fields were flagged as "probably abnormal." This percentage was greatest among the noninsulin-dependent patients with mild background diabetic retinopathy (72.3%). The sensitivity reductions observed in the noninsulin-dependent patients with mild background diabetic retinopathy tended to be localized in the superior quadrants and correlated with the extent of retinal vascular compromise evident from vitreous fluorophotometry (r = 0.603). These findings imply that in diabetic patients visual field defects (1) often can be detected in patients with at most moderate retinopathy, (2) occur more frequently in noninsulin-dependent patients than in insulin-dependent patients, and (3) may result from subclinical microangiopathy.